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CATH Superfamily 1.10.760.10

Cytochrome c-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome c-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20055: Alcohol dehydrogenase cytochrome c subunit

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Gluconate 2-dehydrogenase (acceptor). [EC: 1.1.99.3]
D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor.
    		 256 A0A060V268 A0A060V268 A0A085GUV1 A0A085GUV1 A0A085HCE4 A0A085HCE4 A0A085JKN6 A0A085JKN6 A0A088TY41 A0A088TY41
    (246 more...)
    Nicotinate dehydrogenase (cytochrome). [EC: 1.17.2.1]
    Nicotinate + a ferricytochrome + H(2)O = 6-hydroxynicotinate + a ferrocytochrome + 2 H(+).
    • This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family.
    • While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase.
    		 6 A0A1A0DE11 A0A1A0DE11 C7JAW7 C7JAW7 S6DB18 S6DB18
    Alcohol dehydrogenase (quinone). [EC: 1.1.5.5]
    Ethanol + ubiquinone = acetaldehyde + ubiquinol.
    • Only described in acetic acid bacteria where it is involved in acetic acid production.
    • Associated with membrane.
    • Electron acceptor is membrane ubiquinone.
    • A model structure suggests that, like all other quinoprotein alcohol dehydrogenases, the catalytic subunit has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ; the catalytic subunit also has a heme c in the C-terminal domain.
    • The enzyme has two additional subunits, one of which contains three molecules of heme c.
    • It does not require amines for activation.
    • It has a restricted substrate specificity, oxidizing a few primary alcohols (C2 to C6), but not methanol, secondary alcohols and some aldehydes.
    • It is assayed with phenazine methosulfate or with ferricyanide.
    		 2 A0A0U5B923 A0A0U5B923