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CATH Superfamily 1.10.730.10

Isoleucyl-tRNA Synthetase; Domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Isoleucyl-tRNA Synthetase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
14239
Probable methionine--tRNA ligase, cytoplasmic
11833
EC
3D
 1rqgA04 - 91.5
14311
Leucine--tRNA ligase 1
9031
EC
 - - 89.9
13311
Valine--tRNA ligase
8067
EC
 - - 92.8
14330
Probable methionine--tRNA ligase, mitochondrial
6977
EC
3D
 1f4lA03 - 94.4
14265
Leucine--tRNA ligase subunit beta
6961
EC
3D
 3zgzA04 - 95.6
13688
Valyl-tRNA synthetase
Valine--tRNA ligase ValRS
6935
EC
 - - 92.5
14344
Glycine--tRNA ligase beta subunit
6823
EC
 - - 90.2
14115
Arginine--tRNA ligase
6687
EC
 - - 96.6
14320
Arginine--tRNA ligase 2
6500
EC
 - - 94.8
14082
Probable isoleucine--tRNA ligase, cytoplasmic
6380
EC
3D
 1ileA03 - 92.1
14150
Arginine--tRNA ligase
6218
EC
 - - 95.3
14159
Arginine--tRNA ligase
4140
EC
 - - 93.8
13751
Arginine--tRNA ligase
2023
EC
 - - 87.7
14065
Isoleucine--tRNA ligase
1842
EC
 - - 90.4
14143
Valine--tRNA ligase
1822
EC
 - - 90.5
14397
Putative leucine--tRNA ligase, cytoplasmic
1623
EC
3D
 1wkbA03 - 96.6
14020
Similar to valyl-trna synthetase
1113
EC
 - - 92.2
13609
Valine--tRNA ligase
860
EC
 - - 90.2
14289
Arginyl-tRNA synthetase 2, mitochondrial
829
EC
3D
 1bs2A02 - 95.6
13031
Leucyl-tRNA synthetase
755
EC
 - - 46.5
14379
Leucine--tRNA ligase
617
EC
 - - 92.0
12957
Valine--tRNA ligase
599
EC
 - - 94.1
14108
Arginine--tRNA ligase
461
EC
3D
 2zueA03 - 98.3
14017
Probable arginine--tRNA ligase, cytoplasmic
409
EC
 - - 88.2
9139
Arginine--tRNA ligase
392
EC
 - - 39.4
5303
Methionine--tRNA ligase
339
EC
 - - 43.7
14413
Probable methionine--tRNA ligase, cytoplasmic
255
EC
3D
 2csxA03 - 98.9
13728
Valine--tRNA ligase
239
EC
 - - 84.3
1288
Valine--tRNA ligase
223
EC
 - - 6.3
14178
Arginine--tRNA ligase
196
EC
3D
 3fnrA01 - 78.9
14301
Valine--tRNA ligase
177
EC
 - - 95.3
14175
DALR anticodon binding domain protein
133
EC
 - - 69.1
14377
Probable leucine--tRNA ligase, mitochondrial
114
EC
 - - 84.3
14414
Arginine--tRNA ligase
108
EC
 - - 99.8
318
Valine--tRNA ligase
92
EC
 - - 28.4
1297
Msm1p
88
EC
 - - 1.4
14387
Methionine--tRNA ligase
68
EC
 - - 84.9
13460
Valine--tRNA ligase
56
EC
3D
 1gaxA02 - 75.1
5300
Methionine--tRNA ligase
50
EC
 - - 19.3
6926
Leucine--tRNA ligase, mitochondrial
50
EC
 - - 14.4
9383
Arginyl-tRNA synthetase
49
EC
 - - 0.0
14004
Glycine--tRNA ligase beta subunit
44
EC
 - - 42.3
229
Valine--tRNA ligase
39
EC
 - - 16.0
14394
Glycine--tRNA ligase beta subunit
38
EC
 - - 67.0
5078
Methionine--tRNA ligase
36
EC
 - - 2.1
14213
Leucine--tRNA ligase
35
EC
 - - 6.6
14447
Probable methionine--tRNA ligase, mitochondrial
35
EC
 - - 49.1
13832
Valine--tRNA ligase
31
EC
 - - 60.4
14428
Probable isoleucine--tRNA ligase, cytoplasmic
25
EC
 - - 95.5
14455
Valine-tRNA ligase, putative
24
EC
 - - 58.7
4294
Mitochondrial leucyl-tRNA synthetase, putative
23
EC
 - - 6.8
13681
Leucine--tRNA ligase
22
EC
 - - 40.4
14184
Arginine--tRNA ligase
16
EC
3D
 1iq0A03 - 56.5
13565
Arginine--tRNA ligase
16
EC
 - - 3.9
3218
Mitochondrial methionyl-tRNA synthetase, putative
13
EC
 - - 10.5
14463
Probable isoleucine--tRNA ligase, cytoplasmic
11
EC
 - - 82.0
1461
Isoleucine--tRNA ligase, cytoplasmic
11
EC
 - - 43.0
949
Valine--tRNA ligase
10
EC
 - - 0.0
6045
Probable methionine--tRNA ligase, mitochondrial
9
EC
 - - 11.7
6323
Leucine--tRNA ligase, mitochondrial
8
EC
 - - 6.7
13841
Valine--tRNA ligase
8
EC
 - - 56.1
13097
Methionine--tRNA ligase
7
EC
 - - 1.4
1664
Valine--tRNA ligase
6
EC
 - - 1.0
6150
Methionine--tRNA ligase
6
EC
 - - 2.9
14233
Arginine--tRNA ligase
5
EC
 - - 59.6
5474
Methionine--tRNA ligase
5
EC
 - - 1.4
3382
Valine--tRNA ligase
5
EC
 - - 11.8
8929
CG10092, isoform A
5
EC
 - - 14.7
1038
Valine--tRNA ligase
5
EC
 - - 0.0
10343
Leucine--tRNA ligase
5
EC
 - - 0.8
13927
Lysine--tRNA ligase
4
EC
 - - 0.0
8175
Leucine--tRNA ligase
4
EC
 - - 0.0
1845
Valine--tRNA ligase
4
EC
 - - 1.7
14204
Glycine--tRNA ligase beta subunit
4
EC
 - - 0.0
14228
Arginine--tRNA ligase
3
EC
 - - 38.4
14286
Glycine--tRNA ligase beta subunit
3
EC
 - - 0.0
700
Valine--tRNA ligase
2
EC
 - - 6.1
14369
Arginine--tRNA ligase
2
EC
 - - 44.7
5650
Leucine--tRNA ligase
2
EC
 - - 2.3
91
Valine--tRNA ligase
2
EC
 - - 6.5
3244
Methionyl-tRNA synthetase
2
EC
 - - 3.2
13823
Valine--tRNA ligase
2
EC
 - - 34.7
14304
Probable isoleucine--tRNA ligase, mitochondrial
2
3D
 1qu3A04 - 0.0
14231
Glycine--tRNA ligase beta subunit
2
EC
 - - 42.6
8436
Leucine--tRNA ligase
2
EC
 - - 0.0
1919
Valine--tRNA ligase
2 - - 12.8
10734
Leucine--tRNA ligase
2
EC
 - - 0.8
3368
Isoleucine--tRNA ligase
2
EC
 - - 0.7
12406
Glycine--tRNA ligase beta subunit
1
EC
 - - 0.0
6416
Valine--tRNA ligase
1
EC
 - - 0.0
12175
Methionine--tRNA ligase, cytoplasmic
1 - - 0.0
118
Valyl-tRNA synthetase
1
EC
 - - 0.0
947
Valine--tRNA ligase
1
EC
 - - 0.0
5641
Methionine--tRNA ligase
1
EC
 - - 0.0
848
Valine--tRNA ligase
1
EC
 - - 0.0
10460
Isoleucine--tRNA ligase
1
EC
 - - 0.0
14323
Isoleucine--tRNA ligase, putative
1 - - 0.0
7938
Leucine--tRNA ligase
1
EC
 - - 0.0
14356
Glycine--tRNA ligase beta subunit
1
EC
 - - 0.0
14352
Glycine--tRNA ligase beta subunit
1
EC
 - - 0.0
5513
Uncharacterised protein
1 - -
11126
Leucine--tRNA ligase
1
EC
 - - 0.0
12131
Glycine--tRNA ligase beta subunit
1
EC
 - - 0.0
13945
Glycine--tRNA ligase beta subunit
1
EC
 - - 0.0
1508
Leucine--tRNA ligase, mitochondrial
1
EC
 - - 0.0
538
Valine--tRNA ligase
1
EC
 - - 0.0