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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29426: Cytochrome P450, putative (Eurofung)

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trans-cinnamate 4-monooxygenase. [EC: 1.14.13.11]
Trans-cinnamate + NADPH + O(2) = 4-hydroxycinnamate + NADP(+) + H(2)O.
  • Also acts on NADH, more slowly.
 132 A0A0B2PD37 A0A0B2PD37 A0A0B2PV83 A0A0B2PV83 A0A0B2RE17 A0A0B2RE17 A0A0B2S8D5 A0A0B2S8D5 A0A0G7ZP02 A0A0G7ZP02
(122 more...)
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 8 A0A061IKL8 A0A061IKL8 A0A0F8B2Y5 A0A0F8B2Y5 A0PFJ5 A0PFJ5 A2QAK8 A2QAK8
Aflatoxin B synthase. [EC: 1.14.13.175]
(1) 8-O-methylsterigmatocystin + 2 NADPH + 2 O(2) = aflatoxin B(1) + 2 NADP(+) + H(2)O + methanol + CO(2). (2) 8-O-methyldihydrosterigmatocystin + 2 NADPH + 2 O(2) = aflatoxin B(2) + 2 NADP(+) + H(2)O + methanol + CO(2).
  • Isolated from the mold Aspergillus parasiticus.
 8 A0A0D9MRV9 A0A0D9MRV9 B8NHY4 B8NHY4 O13345 O13345 P0CT93 P0CT93
Cholesterol 24-hydroxylase. [EC: 1.14.14.25]
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = (24S)- cholest-5-ene-3-beta,24-diol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • The enzyme can also produce 25-hydroxycholesterol.
  • In addition, it can further hydroxylate the product to 24,25- dihydroxycholesterol and 24,27-dihydroxycholesterol.
  • This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood- brain barrier whereas cholesterol cannot.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.98.
 6 Q3US73 Q3US73 Q9WVK8 Q9WVK8 Q9Y6A2 Q9Y6A2
Transferred entry: 1.14.14.37. [EC: 1.14.13.68]
    		2 A0A084GEV4 A0A084GEV4
    Ent-cassa-12,15-diene 11-hydroxylase. [EC: 1.14.13.145]
    Ent-cassa-12,15-diene + O(2) + NADPH = ent-11-beta-hydroxycassa-12,15- diene + NADP(+) + H(2)O.
    • A rice, Oryza sativa, enzyme involved in the biosynthesis of the antifungal phytocassanes.
    		 2 A0A084GEV4 A0A084GEV4
    Cholestanetriol 26-monooxygenase. [EC: 1.14.15.15]
    5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin + 6 H(+) + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O.
    • Catalyzes the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway.
    • Can also act on cholesterol, cholest-5-en-3-beta,7-alpha-diol, 7-alpha-hydroxycholest-4-en-3-one, and 5-beta-cholestane-3-alpha,7- alpha-diol.
    • The enzyme can also hydroxylate cholesterol at positions 24 and 25.
    • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
    • Formerly EC 1.14.13.15.
    		 2 H2KYS3 H2KYS3
    Salicylate 1-monooxygenase. [EC: 1.14.13.1]
    Salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).
      		 2 W8E7E3 W8E7E3
      Phenylalanine ammonia-lyase. [EC: 4.3.1.24]
      L-phenylalanine = trans-cinnamate + ammonia.
      • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 and EC 4.3.1.23 and EC 4.3.1.25.
      • The enzyme from some species is highly specific for phenylalanine.
      • Formerly EC 4.3.1.5.
      		 2 J7FTU8 J7FTU8