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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29425: Cytochrome P450 monooxygenase, putative

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fumitremorgin C monooxygenase. [EC: 1.14.13.177]
Fumitremorgin C + 2 NADPH + 2 O(2) = 12-alpha,13-alpha- dihydroxyfumitremorgin C + 2 NADP(+) + 2 H(2)O.
  • Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
 4 A1DA65 B0YAY9 B9WZX6 Q4WAX0
Ent-kaurene oxidase. [EC: 1.14.13.78]
(1) Ent-kaur-16-ene + NADPH + O(2) = ent-kaur-16-en-19-ol + NADP(+) + H(2)O. (2) Ent-kaur-16-en-19-ol + NADPH + O(2) = ent-kaur-16-en-19-al + NADP(+) + 2 H(2)O. (3) Ent-kaur-16-en-19-al + NADPH + O(2) = ent-kaur-16-en-19-oate + NADP(+) + H(2)O.
  • Requires cytochrome P450.
  • Catalyzes three sucessive oxidations of the 4-methyl group of ent- kaurene giving kaurenoic acid.
 3 A9P5P8 O94142 Q701P2
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 3 A0A0N7Z1V0 A2QVM8 A2RAC7
Dihydromonacolin L hydroxylase. [EC: 1.14.13.197]
Dihydromonacolin L acid + O(2) + NADPH = monacolin L acid + NADP(+) + 2 H(2)O.
  • The dehydration of 3-alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous.
  • The enzyme from fungi also catalyzes the reaction of EC 1.14.13.198.
 2 Q3S2T8 Q9Y7C8
Monacolin L hydroxylase. [EC: 1.14.13.198]
Monacolin L acid + O(2) + NADPH = monacolin J acid + NADP(+) + H(2)O.
  • The enzyme from fungi also catalyzes the reaction of EC 1.14.13.197.
 2 Q3S2T8 Q9Y7C8