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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29366: Cytochrome P450 97B2, chloroplastic

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Epi-isozizaene 5-monooxygenase. [EC: 1.14.13.106]
(+)-epi-isozizaene + 2 NADPH + 2 O(2) = albaflavenone + 2 NADP(+) + 3 H(2)O.
  • This enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyzes two sequential allylic oxidation reactions.
  • The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37 is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
 6 A0A0K2AYT5 A0A0K2AYT5 D6EUR6 D6EUR6 Q9K498 Q9K498
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 6 B9RFU0 B9RFU0 B9S0A8 B9S0A8 B9S3L4 B9S3L4
Beta-farnesene synthase. [EC: 4.2.3.47]
(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate.
    		 4 A0A0K2AYT5 A0A0K2AYT5 Q9K498 Q9K498
    Leukotriene-B(4) 20-monooxygenase. [EC: 1.14.13.30]
    (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa- 6,8,10,14-tetraenoate + NADP(+) + H(2)O.
    • Not identical with EC 1.14.13.34.
    		 4 A0A0B2RKI1 A0A0B2RKI1 A0A0R4J4E0 A0A0R4J4E0
    Carotene epsilon-monooxygenase. [EC: 1.14.99.45]
    Alpha-carotene + O(2) + AH(2) = alpha-cryptoxanthin + A + H(2)O.
    • Also acts on zeinoxanthin to give lutein.
    		 4 A0A0B4SXK9 A0A0B4SXK9 Q6TBX7 Q6TBX7
    Pentalenene oxygenase. [EC: 1.14.13.133]
    Pentalenene + 2 NADPH + 2 O(2) = pentalen-13-al + 2 NADP(+) + 3 H(2)O.
    • The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.
    		 2 Q82IY3 Q82IY3