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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12273: Lanosterol 14-alpha-demethylase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sterol 14-alpha-demethylase. [EC: 1.14.13.70]
A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
  • This heme-thiolate (P450) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol.
  • The enzyme catalyzes two successive hydroxylations of the 14-alpha- methyl group, followed by elimination as formate, leaving a 14(15) double bond.
 7 A0A0U2LVU0 A0A165XK35 A0A1E1EUL0 E3VXU9 Q5UQI3 V5L2E5 W6GWN5