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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9660: Geranylgeranyl pyrophosphate synthase A

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Geranylgeranyl diphosphate synthase. [EC: 2.5.1.29]
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
  • Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
 60 A0A024R3W4 A0A0B0E3G4 A0A0B5J9B1 A0A0E1BW66 A0A0K0QS75 A0A0P4UMU8 A0A150IL71 A0A150ITN7 A0A150J190 A0A168Q7N2
(50 more...)
Dimethylallyltranstransferase. [EC: 2.5.1.1]
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
  • Will not accept larger prenyl diphosphates as efficient donors.
 48 A0A024R3W4 A0A0B0E3G4 A0A0B3APG7 A0A0B5HFM6 A0A0E1BW66 A0A0F4YMP6 A0A0J5Q148 A0A0J6F839 A0A0P4UMU8 A0A168Q7N2
(38 more...)
(2E,6E)-farnesyl diphosphate synthase. [EC: 2.5.1.10]
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
  • Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate.
  • The enzyme will not accept larger prenyl diphosphates as efficient donors.
 47 A0A024R3W4 A0A098EFE8 A0A0B0E3G4 A0A0E1BW66 A0A0F3PXN4 A0A0F8D0C5 A0A0P4UMU8 A0A168Q7N2 A0A181ZJ22 A0A182A1Q7
(37 more...)
Geranylfarnesyl diphosphate synthase. [EC: 2.5.1.81]
Geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)- geranylfarnesyl diphosphate + diphosphate.
  • The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis.
  • It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate.
  • The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate.
  • The enzyme is involved in the biosynthesis of C(25)-C(25) membrane lipids.
  • Formerly EC 2.5.1.n2.
 29 A0A0E3L5X4 A0A0E3LMT8 A0A0E3NCY4 A0A0E3NF18 A0A0E3NL12 A0A0E3NS04 A0A0E3P8E8 A0A0E3PHX8 A0A0E3PSS6 A0A0E3PW89
(19 more...)
Fusicocca-2,10(14)-diene synthase. [EC: 4.2.3.43]
Geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate.
  • A multifunctional enzyme with EC 2.5.1.29 activity.
 2 A2PZA5 C9K2Q3
Ent-copalyl diphosphate synthase. [EC: 5.5.1.13]
Geranylgeranyl diphosphate = ent-copalyl diphosphate.
  • Part of a bifunctional enzyme involved in the biosynthesis of kaurene.
  • See also EC 4.2.3.19.
 1 B8MPJ9
Ophiobolin F synthase. [EC: 4.2.3.145]
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H(2)O = ophiobolin F + diphosphate.
  • Isolated from the fungus Aspergillus clavatus.
  • The product is a sesterterpenoid (C(25) terpenoid).
 1 A1C8C3
UDP-N-acetylmuramate dehydrogenase. [EC: 1.3.1.98]
UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.
  • NADH can to a lesser extent replace NADPH.
  • Formerly EC 1.1.1.158.
 1 A0A0L1HPV3
Aristolochene synthase. [EC: 4.2.3.9]
(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate.
  • The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene.
  • While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23).
  • Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
  • Formerly EC 2.5.1.40 and EC 4.1.99.7.
 1 A2R6J8
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