View in Gene3D

CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 9584: Phytoene synthase crtB

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
15-cis-phytoene synthase. [EC: 2.5.1.32]
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.
  • The enzyme produces 15-cis-phytoene.
  • Cf. EC 2.5.1.99.
 17 A0A0E9BCQ1 A0A0K2P5V5 A0A0N1S1B1 A0A0S2IAM7 A0A0U5L0T8 C7C5A3 C7C5F2 C9Y0F0 D4GFK9 D6YQF7
(7 more...)
All-trans-phytoene synthase. [EC: 2.5.1.99]
2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate.
  • The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene.
  • Cf. EC 2.5.1.32.
 5 A0A0E9BCQ1 A0A0N1S1B1 D4GFK9 D5KXJ0 P21683
Squalene synthase. [EC: 2.5.1.21]
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
  • This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols.
  • In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated.
  • When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP).
  • High concentrations of FPP inhibit the production of squalene but not of PSPP.
 3 C7C5A3 C7C5F2 C9Y0F0