View in Gene3D

CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 9556: Farnesyl pyrophosphate synthase 2

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(2E,6E)-farnesyl diphosphate synthase. [EC: 2.5.1.10]
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
  • Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate.
  • The enzyme will not accept larger prenyl diphosphates as efficient donors.
 94 A0A076JDS1 A0A0G2T690 A0A0K8TTD7 A0A0L1HZY1 A0A0L8VMT3 A0A0P4UMM7 A0A162QQB3 A0A178UUX8 A3LU92 A5A7A4
(84 more...)
Dimethylallyltranstransferase. [EC: 2.5.1.1]
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
  • Will not accept larger prenyl diphosphates as efficient donors.
 73 A0A024S6R9 A0A0B2PYM7 A0A0B2S247 A0A0F4Z2C6 A0A0F8BX64 A0A0L8VMT3 A0A0P4UMM7 A0A178UUX8 A5A7A4 A5A7A5
(63 more...)
Chrysanthemyl diphosphate synthase. [EC: 2.5.1.67]
2 dimethylallyl diphosphate = diphosphate + chrysanthemyl diphosphate.
  • Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage; it is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head- to-tail.
  • The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis.
  • Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums.
 3 A0A084FXT2 P0C565 Q7XYS8
(2Z,6E)-farnesyl diphosphate synthase. [EC: 2.5.1.68]
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)- farnesyl diphosphate.
  • The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan.
  • Neryl diphosphate can also act as substrate.
 2 A0A0G3BFY6 F6KUJ4
Lavandulyl diphosphate synthase. [EC: 2.5.1.69]
2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate.
  • Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage; it is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head- to-tail.
  • When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate.
  • The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67) when dimethylally diphosphate is the sole substrate.
 2 A0A084FXT2 Q7XYS8
Geranylgeranyl diphosphate synthase. [EC: 2.5.1.29]
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
  • Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
 1 O59703
CATH-Gene3D is a Global Biodata Core Resource Learn more...