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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9540: Squalene synthase 2

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Squalene synthase. [EC: 2.5.1.21]
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
  • This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols.
  • In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated.
  • When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP).
  • High concentrations of FPP inhibit the production of squalene but not of PSPP.
 107 A0A088RZZ0 A0A0A6ZA44 A0A0B2R0H3 A0A0B2S6C9 A0A0B7FJ97 A0A0D2NGI3 A0A0F4Z0U4 A0A0F8DBD7 A0A0J5PJJ0 A0A0K2F2K4
(97 more...)
Botryococcus squalene synthase. [EC: 1.3.1.96]
Squalene + diphosphate + NADP(+) = presqualene diphosphate + NADPH.
  • Isolated from the green alga Botryococcus braunii BOT22.
  • Acts in the reverse direction.
  • cf. EC 2.5.1.21, where squalene is formed directly from farnesyl diphosphate.
 2 A0A084G2A0 G0Y287
(2E,6E)-farnesyl diphosphate synthase. [EC: 2.5.1.10]
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
  • Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate.
  • The enzyme will not accept larger prenyl diphosphates as efficient donors.
 2 A0A0P4U5E8 G2QHV0
Presqualene diphosphate synthase. [EC: 2.5.1.103]
2 (2E,6E)-farnesyl diphosphate = presqualene diphosphate + diphosphate.
  • Isolated from the green alga Botryococcus braunii BOT22.
  • Unlike EC 2.5.1.21, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme.
  • This compound is then converted into either squalene (by EC 1.3.1.96) or botryococcene (EC 1.3.1.97).
 1 G0Y286
Botryococcene synthase. [EC: 1.3.1.97]
C(30) botryococcene + NADP(+) + diphosphate = presqualene diphosphate + NADPH.
  • Isolated from the green alga Botryococcus braunii BOT22.
  • Acts in the reverse direction.
  • Involved in the production of botryococcenes, which are triterpenoid hydrocarbons of isoprenoid origin produced in large amount by this alga.
 1 G0Y288
Geranylgeranyl diphosphate synthase. [EC: 2.5.1.29]
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
  • Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
 1 A2QYN6