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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 511: Beta-myrcene/(E)-beta-ocimene synthase 2, chloropl...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Myrcene synthase. [EC: 4.2.3.15]
Geranyl diphosphate = myrcene + diphosphate.
  • Mg(2+) is essentially ineffective as the divalent metal ion cofactor.
  • Formerly EC 4.1.99.9.
 2 Q9LRZ6 Q9ZUH4
(E)-beta-ocimene synthase. [EC: 4.2.3.106]
Geranyl diphosphate = (E)-beta-ocimene + diphosphate.
  • Widely distributed in plants, which release beta-ocimene when attacked by herbivorous insects.
 2 A4FVP2 Q9ZUH4
Alpha-farnesene synthase. [EC: 4.2.3.46]
(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate.
    		 2 A4FVP2 P0CJ43
    1,8-cineole synthase. [EC: 4.2.3.108]
    Geranyl diphosphate + H(2)O = 1,8-cineole + diphosphate.
    • 1,8-cineole is the main product from the enzyme with just traces of other monoterpenoids.
    • The oxygen atom is derived from water.
    • The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism.
    • However neither intermediate can substitute for geranyl diphosphate.
    • The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)- linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate.
    		 2 P0DI76 P0DI77
    Tricyclene synthase. [EC: 4.2.3.105]
    Geranyl diphosphate = tricyclene + diphosphate.
    • The enzyme from Solanum lycopersicum (tomato) gives a mixture of tricyclene, camphene, beta-myrcene, limonene, and traces of several other monoterpenoids.
    • See EC 4.2.3.117, EC 4.2.3.15 and EC 4.2.3.16.
    		 2 A4FVP2 Q9ZUH4
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