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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79517: Serine/Threonine kinase domain protein

There are 17 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 202 A0A061HXB0 A0A061HXB0 A0A061HZG0 A0A061HZG0 A0A077TH02 A0A077TH02 A0A088RHJ8 A0A088RHJ8 A0A088RY29 A0A088RY29
(192 more...)
Mitogen-activated protein kinase kinase kinase. [EC: 2.7.11.25]
ATP + a protein = ADP + a phosphoprotein.
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
 58 A0A0A1TV69 A0A0A1TV69 A0A0A1U516 A0A0A1U516 A0A0A1UFA5 A0A0A1UFA5 A0A0A1UH52 A0A0A1UH52 B0E5H8 B0E5H8
(48 more...)
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 50 A0A060RQ58 A0A060RQ58 A0A0A1TWS8 A0A0A1TWS8 A0A0A1TXZ1 A0A0A1TXZ1 A0A0A1TYV7 A0A0A1TYV7 A0A0A1U443 A0A0A1U443
(40 more...)
Mitogen-activated protein kinase kinase. [EC: 2.7.12.2]
ATP + a protein = ADP + a phosphoprotein.
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
 48 A0A0A1TYH3 A0A0A1TYH3 A0A0A1U0Z4 A0A0A1U0Z4 A0A0B2PBE9 A0A0B2PBE9 A0A0B2SH46 A0A0B2SH46 A0A0N7FRS8 A0A0N7FRS8
(38 more...)
Dual-specificity kinase. [EC: 2.7.12.1]
ATP + a protein = ADP + a phosphoprotein.
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
 26 A0A0B2PIG2 A0A0B2PIG2 A0A0B2R1V3 A0A0B2R1V3 A0A0B2RRM2 A0A0B2RRM2 A0A0B2SS11 A0A0B2SS11 A0A0B7FRY4 A0A0B7FRY4
(16 more...)
Calcium/calmodulin-dependent protein kinase. [EC: 2.7.11.17]
ATP + a protein = ADP + a phosphoprotein.
  • Requires calmodulin.
  • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
  • Not identical with EC EC 2.7.11.18 or EC 2.7.11.26.
  • Formerly EC 2.7.1.120 and EC 2.7.1.123.
 20 A0A0A1TVR6 A0A0A1TVR6 A0A0A1U3Z8 A0A0A1U3Z8 A0A0A1UEM3 A0A0A1UEM3 A0A0W0SLR4 A0A0W0SLR4 B0EQ85 B0EQ85
(10 more...)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
 14 A0A0A1U6B8 A0A0A1U6B8 B0E5H8 B0E5H8 B0EBV8 B0EBV8 B0ECR1 B0ECR1 B0EIQ6 B0EIQ6
(4 more...)
Cyclin-dependent kinase. [EC: 2.7.11.22]
ATP + a protein = ADP + a phosphoprotein.
  • Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin.
  • It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
  • Formerly EC 2.7.1.37.
 8 A0A0A1UBE2 A0A0A1UBE2 A0A0A1UGS6 A0A0A1UGS6 F0SLA2 F0SLA2 L7FNB0 L7FNB0
[Tau protein] kinase. [EC: 2.7.11.26]
ATP + [tau protein] = ADP + [tau protein] phosphate.
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
 4 B0ET57 B0ET57 B0ET57 B0ET57
Furin. [EC: 3.4.21.75]
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
  • Activated by calcium.
  • Belongs to peptidase family S8.
 4 B0EHX4 B0EHX4 B0ELZ4 B0ELZ4
[RNA-polymerase]-subunit kinase. [EC: 2.7.11.23]
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
  • Appears to be distinct from other protein phosphokinases.
  • Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6.
  • Does not phosphorylate casein, phosvitin or histone.
  • Formerly EC 2.7.1.141.
 2 A0A0A1TWZ9 A0A0A1TWZ9
Polo kinase. [EC: 2.7.11.21]
ATP + a protein = ADP + a phosphoprotein.
  • The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation.
  • The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein.
  • Formerly EC 2.7.1.37.
 2 G0QIZ9 G0QIZ9
Coagulation factor Xa. [EC: 3.4.21.6]
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
  • A blood coagulation factor formed from the proenzyme factor X by limited proteolysis.
  • Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds.
  • The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids.
  • Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
  • Belongs to peptidase family S1.
 2 B0ELZ4 B0ELZ4
Beta-glucuronidase. [EC: 3.2.1.31]
A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol.
    		 2 B0ERH3 B0ERH3
    Sodium-transporting two-sector ATPase. [EC: 3.6.3.15]
    ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).
    • A multisubunit non-phosphorylated ATPase that is involved in the transport of ions.
    • An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14.
    		 2 B0E5H8 B0E5H8
    Limulus clotting factor C. [EC: 3.4.21.84]
    Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro- Arg-|-Xaa- bonds in synthetic substrates.
    • From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus.
    • Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin.
    • Inhibited by antithrombin III.
    • Belongs to peptidase family S1.
    		 2 B0ELZ4 B0ELZ4
    Type 1 galactoside alpha-(1,2)-fucosyltransferase. [EC: 2.4.1.69]
    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-R.
    • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
    • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
    • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
    • Formerly EC 2.4.1.89.
    		 2 G0QIZ9 G0QIZ9