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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79235: Serine/Threonine kinase domain protein

There are 22 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 536 A0A024R8A6 A0A024R8A6 A0A024R964 A0A024R964 A0A024VA93 A0A024VA93 A0A024W9Q1 A0A024W9Q1 A0A060RQZ1 A0A060RQZ1
(526 more...)
Mitogen-activated protein kinase kinase kinase. [EC: 2.7.11.25]
ATP + a protein = ADP + a phosphoprotein.
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
 98 A0A074SML6 A0A074SML6 A0A074SX93 A0A074SX93 A0A074TRT9 A0A074TRT9 A0A086J6R9 A0A086J6R9 A0A086JBE4 A0A086JBE4
(88 more...)
Mitogen-activated protein kinase kinase. [EC: 2.7.12.2]
ATP + a protein = ADP + a phosphoprotein.
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
 58 A0A074STA9 A0A074STA9 A0A086J7K5 A0A086J7K5 A0A086K2Z7 A0A086K2Z7 A0A086KEQ1 A0A086KEQ1 A0A086KFI6 A0A086KFI6
(48 more...)
Calcium/calmodulin-dependent protein kinase. [EC: 2.7.11.17]
ATP + a protein = ADP + a phosphoprotein.
  • Requires calmodulin.
  • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
  • Not identical with EC EC 2.7.11.18 or EC 2.7.11.26.
  • Formerly EC 2.7.1.120 and EC 2.7.1.123.
 52 A0A074SYI0 A0A074SYI0 A0A086JIJ6 A0A086JIJ6 A0A086JU01 A0A086JU01 A0A086KRG6 A0A086KRG6 A0A086LS81 A0A086LS81
(42 more...)
Transferred entry: 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1. [EC: 2.7.1.37]
    		28 A0A1G4I553 A0A1G4I553 A0A1G4I975 A0A1G4I975 C9ZKX6 C9ZKX6 Q1JT98 Q1JT98 Q4GYR0 Q4GYR0
    (18 more...)
    [Myosin light-chain] kinase. [EC: 2.7.11.18]
    ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
    • Requires calmodulin for activity.
    • The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly.
    • Formerly EC 2.7.1.117.
    		 22 A0A074SKT5 A0A074SKT5 A0A086K0J3 A0A086K0J3 A0A086KSU2 A0A086KSU2 A0A086L256 A0A086L256 A0A086M7C7 A0A086M7C7
    (12 more...)
    Protein kinase C. [EC: 2.7.11.13]
    ATP + a protein = ADP + a phosphoprotein.
    • A family of serine- and threonine-specific protein kinases that depend on lipids for activity.
    • They can be activated by calcium but have a requirement for the second messenger diacylglycerol.
    • Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways.
    • Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters.
    • Formerly EC 2.7.1.37.
    		 8 B9RSY9 B9RSY9 G0QJS5 G0QJS5 Q9VC32 Q9VC32 Q9W3N8 Q9W3N8
    Receptor protein-tyrosine kinase. [EC: 2.7.10.1]
    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
    • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
    • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
    • Formerly EC 2.7.1.112.
    		 6 A0A0F7U9W4 A0A0F7U9W4 F0VA86 F0VA86 G0QPE4 G0QPE4
    Polo kinase. [EC: 2.7.11.21]
    ATP + a protein = ADP + a phosphoprotein.
    • The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation.
    • The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein.
    • Formerly EC 2.7.1.37.
    		 6 G0QSF0 G0QSF0 G0R064 G0R064 G0R2F6 G0R2F6
    NADH:ubiquinone reductase (H(+)-translocating). [EC: 1.6.5.3]
    NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
    • The complex is present in mitochondria and aerobic bacteria.
    • Breakdown of the complex can release EC 1.6.99.3.
    • In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH.
    		 6 G0QZ02 G0QZ02 G0R1P2 G0R1P2 G0R262 G0R262
    Type 1 galactoside alpha-(1,2)-fucosyltransferase. [EC: 2.4.1.69]
    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-R.
    • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
    • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
    • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
    • Formerly EC 2.4.1.89.
    		 6 G0R0T4 G0R0T4 G0R2F6 G0R2F6 G0R2T6 G0R2T6
    DNA helicase. [EC: 3.6.4.12]
    ATP + H(2)O = ADP + phosphate.
    • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
    • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
    • Some helicases unwind DNA as well as RNA (4,9).
    • May be identical with EC 3.6.4.13 (RNA helicase).
    		 4 A0A0S8GNF4 A0A0S8GNF4 A0A1F4UAY7 A0A1F4UAY7
    1-phosphatidylinositol-3-phosphate 5-kinase. [EC: 2.7.1.150]
    ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,5-bisphosphate.
      		 4 G0QM22 G0QM22 G0R5V5 G0R5V5
      Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
      ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
      • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
      • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
      • Formerly EC 2.7.1.112.
      		 4 G0QU87 G0QU87 G0R2P6 G0R2P6
      Bontoxilysin. [EC: 3.4.24.69]
      Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
      • Belongs to peptidase family M27.
      		 2 G0QSF0 G0QSF0
      Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
      NTP + H(2)O = NDP + phosphate.
      • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
      • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
      • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
      		 2 G0R2P6 G0R2P6
      Dual-specificity kinase. [EC: 2.7.12.1]
      ATP + a protein = ADP + a phosphoprotein.
      • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
      • Formerly EC 2.7.1.37.
      		 2 G0R1Y3 G0R1Y3
      Triacylglycerol lipase. [EC: 3.1.1.3]
      Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
      • The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
      		 2 G0R4B0 G0R4B0
      Peptidylprolyl isomerase. [EC: 5.2.1.8]
      Peptidylproline (omega=180) = peptidylproline (omega=0).
      • The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A.
      • Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli.
      • The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
      		 2 G0QVK4 G0QVK4
      Glycylpeptide N-tetradecanoyltransferase. [EC: 2.3.1.97]
      Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
      • The enzyme from Saccharomyces cerevisiae is highly specific for tetradecanoyl-CoA, and for N-terminal glycine in oligopeptides containing serine in the 5-position.
      • The enzyme from mammalian heart transfers acyl groups to a specific acceptor protein of 51 kDa.
      		 2 G0QQ64 G0QQ64
      Cyclin-dependent kinase. [EC: 2.7.11.22]
      ATP + a protein = ADP + a phosphoprotein.
      • Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin.
      • It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
      • Formerly EC 2.7.1.37.
      		 2 A0A084FWA7 A0A084FWA7
      Acylglycerol lipase. [EC: 3.1.1.23]
      Hydrolyzes glycerol monoesters of long-chain fatty acids.
        		 2 G0QZ02 G0QZ02