The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 78246: AP2-associated protein kinase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
8 | F1MH24 (/ISS) F1SPM8 (/ISS) Q2M2I8 (/ISS) Q3UHJ0 (/ISS) Q7KT38 (/ISS) Q9U485 (/ISS) Q9VJ30 (/ISS) X2J946 (/ISS) |
|
AP-2 adaptor complex binding GO:0035612
Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
|
6 | P0C1X8 (/IDA) Q2M2I8 (/IDA) Q7KT38 (/IDA) Q9U485 (/IDA) Q9VJ30 (/IDA) X2J946 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | Q2M2I8 (/IPI) Q7KT38 (/IPI) Q9U485 (/IPI) Q9VJ30 (/IPI) X2J946 (/IPI) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
4 | Q7KT38 (/NAS) Q9U485 (/NAS) Q9VJ30 (/NAS) X2J946 (/NAS) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) P0C1X8 (/ISS) Q3UHJ0 (/ISS) |
|
PTB domain binding GO:0051425
Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein.
|
4 | Q7KT38 (/IPI) Q9U485 (/IPI) Q9VJ30 (/IPI) X2J946 (/IPI) |
|
AP-2 adaptor complex binding GO:0035612
Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
|
3 | F1MH24 (/ISS) F1SPM8 (/ISS) Q3UHJ0 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q91Z96 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | P0C1X8 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q2M2I8 (/TAS) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
1 | Q2M2I8 (/IDA) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
1 | Q3UHJ0 (/ISO) |
|
Phosphatase regulator activity GO:0019208
Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
|
1 | Q91Z96 (/IDA) |
|
AP-2 adaptor complex binding GO:0035612
Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
|
1 | Q3UHJ0 (/ISO) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
6 | F1MH24 (/ISS) Q3UHJ0 (/ISS) Q7KT38 (/ISS) Q9U485 (/ISS) Q9VJ30 (/ISS) X2J946 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
4 | Q7KT38 (/NAS) Q9U485 (/NAS) Q9VJ30 (/NAS) X2J946 (/NAS) |
|
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
4 | Q7KT38 (/IMP) Q9U485 (/IMP) Q9VJ30 (/IMP) X2J946 (/IMP) |
|
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
4 | Q7KT38 (/IPI) Q9U485 (/IPI) Q9VJ30 (/IPI) X2J946 (/IPI) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) P0C1X8 (/ISS) Q3UHJ0 (/ISS) |
|
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) P0C1X8 (/ISS) Q3UHJ0 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) Q2M2I8 (/ISS) Q3UHJ0 (/ISS) |
|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.
|
4 | Q7KT38 (/IMP) Q9U485 (/IMP) Q9VJ30 (/IMP) X2J946 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) P0C1X8 (/ISS) Q3UHJ0 (/ISS) |
|
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
|
4 | Q7KT38 (/IGI) Q9U485 (/IGI) Q9VJ30 (/IGI) X2J946 (/IGI) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | F1SPM8 (/IDA) P0C1X8 (/IDA) Q2M2I8 (/IDA) |
|
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
|
3 | F1SPM8 (/IDA) P0C1X8 (/IDA) Q2M2I8 (/IDA) |
|
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
|
2 | F1MH24 (/ISS) Q3UHJ0 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q3UHJ0 (/ISO) |
|
Regulation of bone mineralization GO:0030500
Any process that modulates the frequency, rate or extent of bone mineralization.
|
1 | Q91Z96 (/IDA) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q2M2I8 (/IDA) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q3UHJ0 (/ISO) |
|
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
|
1 | Q2M2I8 (/IDA) |
|
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
|
1 | Q3UHJ0 (/ISO) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | P0C1X8 (/IDA) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q2M2I8 (/IDA) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q3UHJ0 (/ISO) |
|
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
|
1 | Q2M2I8 (/TAS) |
|
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
|
1 | Q2M2I8 (/IMP) |
|
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
|
1 | Q3UHJ0 (/ISO) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extrinsic component of plasma membrane GO:0019897
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
4 | F1SPM8 (/ISS) P0C1X8 (/ISS) Q2M2I8 (/ISS) Q3UHJ0 (/ISS) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
4 | Q7KT38 (/IDA) Q9U485 (/IDA) Q9VJ30 (/IDA) X2J946 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
4 | Q7KT38 (/IDA) Q9U485 (/IDA) Q9VJ30 (/IDA) X2J946 (/IDA) |
|
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) Q2M2I8 (/ISS) Q3UHJ0 (/ISS) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
4 | Q7KT38 (/IDA) Q9U485 (/IDA) Q9VJ30 (/IDA) X2J946 (/IDA) |
|
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
4 | F1MH24 (/ISS) F1SPM8 (/ISS) Q2M2I8 (/ISS) Q3UHJ0 (/ISS) |
|
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
|
3 | F1MH24 (/ISS) Q2M2I8 (/ISS) Q3UHJ0 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q91Z96 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q2M2I8 (/TAS) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q9NSY1 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q91Z96 (/ISO) |
|
Extrinsic component of plasma membrane GO:0019897
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | F1MH24 (/IDA) |
|
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
|
1 | F1SPM8 (/IDA) |
|
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
|
1 | P0C1X8 (/IDA) |
|
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
1 | P0C1X8 (/IDA) |
|
Clathrin complex GO:0071439
A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.
|
1 | P0C1X8 (/IDA) |