The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cyclin-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9888: Transcription initiation factor IIB

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P29052 (/IPI) P29056 (/IPI) P48512 (/IPI) Q00403 (/IPI) Q9VEL2 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
3 P29052 (/IPI) Q00403 (/IPI) Q9VEL2 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P29056 (/IDA) P62915 (/IDA)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
2 P29055 (/IPI) Q00403 (/IPI)
RDNA binding GO:0000182
Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.
1 O23215 (/IDA)
RNA polymerase II core binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
1 P29055 (/IDA)
RNA polymerase II core binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
1 P29055 (/IPI)
RNA polymerase III core binding GO:0000994
Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
1 P29056 (/IDA)
RNA polymerase III core binding GO:0000994
Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
1 P29056 (/IPI)
TFIIIB-type transcription factor activity GO:0001026
Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
1 P29056 (/IC)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P62915 (/IDA)
RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0001129
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 P29055 (/IDA)
RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0001129
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 P29055 (/IMP)
RNA polymerase II transcription factor activity, TBP-class protein binding GO:0001132
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
1 O13749 (/IDA)
Transcription factor activity, core RNA polymerase II recruiting GO:0001139
Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 P29055 (/IDA)
Transcription factor activity, core RNA polymerase II recruiting GO:0001139
Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 P29055 (/IMP)
Transcription factor activity, core RNA polymerase II recruiting GO:0001139
Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 Q54FD6 (/ISS)
TFIIIC-class transcription factor binding GO:0001156
Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
1 P29056 (/IDA)
TFIIIC-class transcription factor binding GO:0001156
Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
1 P29056 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 P62915 (/ISO)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
1 P29055 (/IDA)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
1 P62915 (/ISO)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q00403 (/IPI)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 P62915 (/ISO)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thrombocyte differentiation GO:0002574
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2 Q5TZ89 (/IMP) Q6P9Z3 (/IMP)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
2 P29052 (/ISS) Q54FD6 (/ISS)
Transcription from RNA polymerase III promoter GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
2 P29056 (/TAS) Q92994 (/TAS)
Transcription initiation from RNA polymerase III promoter GO:0006384
Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
2 P43072 (/ISS) Q54U85 (/ISS)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2 Q5TZ89 (/IMP) Q6P9Z3 (/IMP)
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
2 F1R9S3 (/IMP) Q802Z8 (/IMP)
Neutrophil differentiation GO:0030223
The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
2 F1R9S3 (/IMP) Q802Z8 (/IMP)
RNA polymerase II transcriptional preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
2 P29055 (/IDA) Q00403 (/IDA)
DNA-templated transcriptional open complex formation GO:0001112
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
1 P29056 (/IMP)
Transcriptional open complex formation at RNA polymerase II promoter GO:0001113
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
1 P29055 (/IMP)
Transcriptional start site selection at RNA polymerase II promoter GO:0001174
Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
1 P29052 (/IDA)
Transcriptional start site selection at RNA polymerase II promoter GO:0001174
Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
1 P29055 (/IMP)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P29052 (/IDA)
Regulation of transcription from RNA polymerase III promoter GO:0006359
Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter.
1 Q9VEL2 (/IDA)
Regulation of transcription from RNA polymerase III promoter GO:0006359
Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter.
1 Q9VEL2 (/IPI)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q00403 (/TAS)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 O13749 (/IDA)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 Q00403 (/TAS)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
1 Q00403 (/TAS)
Transcription from RNA polymerase III promoter GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
1 Q9VEL2 (/IDA)
Transcription from RNA polymerase III promoter GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
1 Q54U85 (/ISS)
Transcription initiation from RNA polymerase III promoter GO:0006384
Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 Q92994 (/TAS)
Transcription elongation from RNA polymerase III promoter GO:0006385
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III.
1 P29056 (/TAS)
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
1 Q92994 (/TAS)
TRNA transcription GO:0009304
The synthesis of transfer RNA (tRNA) from a DNA template.
1 Q92994 (/TAS)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 Q9M2L0 (/IMP)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 F4IN86 (/IMP)
Endosperm development GO:0009960
The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo.
1 P48512 (/IMP)
Pollen tube guidance GO:0010183
The process in which the growth of pollen tube is directed towards the female gametophyte.
1 P48512 (/IMP)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
1 Q9VEL2 (/IMP)
SnRNA transcription from RNA polymerase II promoter GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
1 Q00403 (/TAS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
1 Q8CFK2 (/IMP)
Positive regulation of transcription from RNA polymerase III promoter GO:0045945
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter.
1 D4A8W8 (/IMP)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q9VEL2 (/IMP)
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
1 Q00403 (/IMP)
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
1 P62915 (/ISO)
Regulation of DNA binding GO:0051101
Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 P29052 (/IDA)
RNA polymerase II transcriptional preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 P29055 (/IMP)
RNA polymerase II transcriptional preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
1 P62915 (/ISO)
Microgametogenesis GO:0055046
The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure.
1 Q9M2L0 (/IMP)
Transposon integration GO:0070893
Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome.
1 P29056 (/IDA)
RNA polymerase III transcriptional preinitiation complex assembly GO:0070898
The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.
1 P29056 (/IDA)
RNA polymerase III transcriptional preinitiation complex assembly GO:0070898
The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.
1 P29056 (/IMP)
RNA polymerase III transcriptional preinitiation complex assembly GO:0070898
The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.
1 Q9P6R0 (/ISO)
Regulation of pollen tube growth GO:0080092
Any process that modulates the frequency, rate or extent of pollen tube growth.
1 P48512 (/IMP)
Negative regulation of protein homodimerization activity GO:0090074
Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 P29056 (/IDA)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
1 Q00403 (/IDA)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
1 P62915 (/ISO)
Positive regulation of transcription regulatory region DNA binding GO:2000679
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
1 P29055 (/IDA)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 O13749 (/IDA) P29052 (/IDA) P29055 (/IDA) P48512 (/IDA) P62915 (/IDA) Q00403 (/IDA) Q9M2L0 (/IDA) Q9P6R0 (/IDA) Q9SS44 (/IDA)
Transcription factor TFIIIB complex GO:0000126
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
3 P29056 (/IDA) Q54U85 (/IDA) Q9P6R0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P29056 (/TAS) Q00403 (/TAS) Q92994 (/TAS)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
2 P29055 (/IDA) Q00403 (/IDA)
Transcription factor TFIIIB complex GO:0000126
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
1 P43072 (/ISS)
Transcription factor TFIIIB complex GO:0000126
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
1 Q92994 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q54U85 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P62915 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q54FD6 (/ISS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q9VEL2 (/IPI)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
1 Q00403 (/IDA)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
1 P62915 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9SS44 (/IDA)
Plastid outer membrane GO:0009527
The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope.
1 O23215 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q00403 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 P62915 (/ISO)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
1 P62915 (/ISO)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
1 P29052 (/ISS)