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CATH Superfamily 1.10.45.10

Vanillyl-alcohol Oxidase; Chain A, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vanillyl-alcohol Oxidase; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3341: Probable D-lactate dehydrogenase, mitochondrial

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-lactate dehydrogenase (cytochrome). [EC: 1.1.2.4]
(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).
    		 87 A0A031HT58 A0A060T7G3 A0A073KRR9 A0A098FZZ6 A0A099KXP3 A0A099L8I0 A0A0A1F8H5 A0A0B2QRT4 A0A0B7FCP5 A0A0E0SYP1
    (77 more...)
    (S)-2-hydroxy-acid oxidase. [EC: 1.1.3.15]
    (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
    • Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids.
    • The rat isoenzyme B also acts as EC 1.4.3.2.
    • Formerly EC 1.1.3.1.
    		 55 A0A072P3D3 A0A0A0TUF1 A0A0B5R8Y6 A0A0B5XCG8 A0A0D0GTZ2 A0A0E1LQM3 A0A0G8DII8 A0A0J1HZ50 A0A0J6Z1Y8 A0A0N8VHM8
    (45 more...)
    Glycolate dehydrogenase. [EC: 1.1.99.14]
    Glycolate + acceptor = glyoxylate + reduced acceptor.
    • Also acts on (R)-lactate.
    • 2,6-dichloroindophenol and phenazine methosulfate can act as acceptors.
    		 41 A0A068N7G9 A0A084J520 A0A0B5S7U1 A0A0D1NFJ0 A0A0D6T6G6 A0A0F6JC64 A0A0G8CDB5 A0A0G8EBY3 A0A0J6Z1Y8 A0A0K0HYR3
    (31 more...)
    UDP-N-acetylmuramate dehydrogenase. [EC: 1.3.1.98]
    UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.
    • NADH can to a lesser extent replace NADPH.
    • Formerly EC 1.1.1.158.
    		 8 A0A088SA75 A0A098B1D0 A0A0L1HSK1 A0A1E1IX01 B4L7S3 B4M765 G9XNY1 M5R177
    D-2-hydroxyglutarate dehydrogenase. [EC: 1.1.99.39]
    (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
    • The enzyme has no activity with NAD(+) or NADP(+), and was assayed in vitro using artificial electron acceptors.
    • It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers.
    		 4 A0A1J0LJ95 B8B7X6 O23240 Q7XI14
    D-lactate dehydrogenase. [EC: 1.1.1.28]
    (R)-lactate + NAD(+) = pyruvate + NADH.
      		 1 Q82VQ7