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CATH Superfamily 1.10.420.10

Peroxidase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Peroxidase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4821: Cytochrome c peroxidase, mitochondrial

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cytochrome-c peroxidase. [EC: 1.11.1.5]
2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O.
    		 25 A0A0B0DM11 A0A0D2K581 A0A0J5SCY2 A0A1D8NPB3 A0A1H6Q8P6 A0A1I9EY47 A4QVH4 A5JW30 B5YMA2 C4YQ18
    (15 more...)
    Catalase peroxidase. [EC: 1.11.1.21]
    (1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
    • Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site.
    • In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.
    		 14 A0A0B5GY90 A0A0N0BMZ8 A0A0U1CQM2 A0A165MNW7 G0HTW8 M0JQS4 M0JTU1 M0JYL9 M0KSB2 M0KVM9
    (4 more...)
    L-ascorbate peroxidase. [EC: 1.11.1.11]
    2 L-ascorbate + H(2)O(2) + 2 H(+) = L-ascorbate + L-dehydroascorbate + 2 H(2)O.
    • Oxidizes ascorbate and low molecular weight aromatic substrates.
    • The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 or undergoes non-enzymatic disproportionation to ascorbate and dehydroascorbate.
    		 14 A0A088RQL7 A4HAD2 A4I9H5 B7G1J9 B8CFA9 E9B4H3 E9BQG1 H6V7N3 Q4CRX7 Q4D2P4
    (4 more...)