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CATH Superfamily 1.10.40.30

Fumarase/aspartase (C-terminal domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Fumarase/aspartase (C-terminal domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5364: Fumarate hydratase class II

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fumarate hydratase. [EC: 4.2.1.2]
(S)-malate = fumarate + H(2)O.
    		 2555 A0A009EGV3 A0A011A126 A0A011MI44 A0A011UGM4 A0A017HFC3 A0A017HTP1 A0A021X3U7 A0A022SWA5 A0A023P5B3 A0A023XNL1
    (2545 more...)
    Succinate dehydrogenase (quinone). [EC: 1.3.5.1]
    Succinate + a quinone = fumarate + a quinol.
    • The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria.
    • It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II).
    • In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone.
    • Cf. EC 1.3.5.4.
    		 2 A0A151PHK6 A0A151PHP8
    Arginase. [EC: 3.5.3.1]
    L-arginine + H(2)O = L-ornithine + urea.
    • Also hydrolyzes alpha-N-substituted L-arginines and canavanine.
    		 1 A0A171A4V3