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CATH Superfamily 1.10.390.10

Neutral Protease Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Neutral Protease Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5143: Membrane alanine aminopeptidase N

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Membrane alanyl aminopeptidase. [EC: 3.4.11.2]
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
  • Is not activated by heavy metal ions.
  • Belongs to peptidase family M1.
  • Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.
 2978 A0A009ETS5 A0A009ETS5 A0A009G2Y1 A0A009G2Y1 A0A009GAX2 A0A009GAX2 A0A009HIB8 A0A009HIB8 A0A009HRD2 A0A009HRD2
(2968 more...)
Ent-cassa-12,15-diene synthase. [EC: 4.2.3.28]
Ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate.
  • This class I diterpene cyclase produces ent-cassa-12,15-diene, a precursor of the rice phytoalexins (-)-phytocassanes A-E. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
 22 A0A0E1X179 A0A0E1X179 A0A0F6APW1 A0A0F6APW1 A0A0M1WED4 A0A0M1WED4 A0A0M2YAC3 A0A0M2YAC3 C0G508 C0G508
(12 more...)
Cytosol alanyl aminopeptidase. [EC: 3.4.11.14]
Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
  • A puromycin-sensitive, cobalt-activated zinc-sialoglycoprotein that is generally cytosolic.
  • Multiple forms are widely distributed in mammalian tissues and body fluids.
 22 A0A098GA14 A0A098GA14 A0A160S8I6 A0A160S8I6 A0A160SLF9 A0A160SLF9 A0A193STC8 A0A193STC8 A0A1A8XQM6 A0A1A8XQM6
(12 more...)
Phosphoribosylaminoimidazole carboxylase. [EC: 4.1.1.21]
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
 2 A5UJ15 A5UJ15
Chloramphenicol O-acetyltransferase. [EC: 2.3.1.28]
Acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate.
  • Chloramphenicol is an antibiotic.
 2 X5MMV2 X5MMV2
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