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CATH Superfamily 1.10.390.10

Neutral Protease Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Neutral Protease Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3516: Thermolysin metallopeptidase, catalytic domain pro...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Coccolysin. [EC: 3.4.24.30]
Preferential cleavage: Xaa-|-Leu, Xaa-|-Phe, Xaa-|-Tyr, Xaa-|-Ala.
  • A 30 kDa endopeptidase found intracellularly in Streptococcus thermophilus and S.diacetilactis and in the medium of Enterococcus faecalis.
  • Belongs to peptidase family M4.
  • Formerly included in EC 3.4.24.4.
 32 A0A059N3R0 A0A0M1ZDS5 A0A0U1B129 A0A0Y4GUS4 A0A112V0K1 A0A125W6M0 C0X654 C7X181 D4ENW0 D4EUQ1
(22 more...)
Aureolysin. [EC: 3.4.24.29]
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residues. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus.
  • Earlier confused with staphylokinase.
  • Belongs to peptidase family M4.
  • Formerly EC 3.4.24.4 and EC 3.4.99.22.
 1 X5NVJ7