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CATH Superfamily 1.10.287.540

Helix hairpin bin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1253: Pyrrolysine--tRNA ligase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyrrolysine--tRNA(Pyl) ligase. [EC: 6.1.1.26]
ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl- tRNA(Pyl).
  • In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl- -tRNA ligase.
  • Specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.
 41 A0A0E3LT83 A0A0E3NCI8 A0A0E3NI21 A0A0E3NQS8 A0A0E3NT95 A0A0E3P323 A0A0E3P9Q4 A0A0E3PIJ4 A0A0E3PZI8 A0A0E3Q9I2
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