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CATH Superfamily 1.10.287.1060

ESAT-6-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
ESAT-6-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 787: Alanine and proline rich protein

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NAD(+) glycohydrolase. [EC: 3.2.2.5]
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
  • This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
  • The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis.
  • The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC 3.6.1.5.
 10 A0A0E8TUT6 A0A0G4DUN0 A0A0H3LN85 A0A0H3MAA9 A0A0H3P6X5 A0A1A9EE63 A5U9N1 F8MAE1 L7N5R3 O05442