The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 971: Guanylyl cyclase-activating protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
6 Q8UUY0 (/IDA) Q8UUY0 (/IDA) Q8VBV8 (/IDA) Q8VBV8 (/IDA) Q90WX3 (/IDA) Q90WX3 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q8UUY0 (/IDA) Q8UUY0 (/IDA) Q90WX3 (/IDA) Q90WX3 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q8UUY0 (/ISS) Q8UUY0 (/ISS) Q90WX3 (/ISS) Q90WX3 (/ISS)
Guanylate cyclase activator activity GO:0030250
Binds to and increases the activity of guanylate cyclase.
4 Q8UUY0 (/ISS) Q8UUY0 (/ISS) Q90WX3 (/ISS) Q90WX3 (/ISS)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
2 Q9UMX6 (/TAS) Q9UMX6 (/TAS)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
2 Q8VBV8 (/IGI) Q8VBV8 (/IGI)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q9UMX6 (/TAS) Q9UMX6 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2 Q9UMX6 (/TAS) Q9UMX6 (/TAS)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
2 Q9UMX6 (/TAS) Q9UMX6 (/TAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 Q8VBV8 (/IMP) Q8VBV8 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 Q8VBV8 (/IMP) Q8VBV8 (/IMP)
Regulation of rhodopsin mediated signaling pathway GO:0022400
Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
2 Q9UMX6 (/TAS) Q9UMX6 (/TAS)
Regulation of guanylate cyclase activity GO:0031282
Any process that modulates the frequency, rate or extent of guanylate cyclase activity.
2 Q8VBV8 (/IGI) Q8VBV8 (/IGI)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.
4 A0A0G2K1Y3 (/IDA) A0A0G2K1Y3 (/IDA) D3ZID7 (/IDA) D3ZID7 (/IDA)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
4 A0A0G2K1Y3 (/IDA) A0A0G2K1Y3 (/IDA) D3ZID7 (/IDA) D3ZID7 (/IDA)
Photoreceptor disc membrane GO:0097381
Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment.
2 Q9UMX6 (/TAS) Q9UMX6 (/TAS)