The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 570: Calcineurin B homologous protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P61023 (/IDA) Q99653 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P61023 (/IPI) Q99653 (/IPI)
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
1 P61023 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P61022 (/ISO)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 P61023 (/IDA)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
1 Q99653 (/TAS)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P61023 (/IDA)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q99653 (/IDA)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 P61022 (/ISO)

There are 57 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
6 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Membrane docking GO:0022406
The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Cytoplasmic microtubule organization GO:0031122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of protein autophosphorylation GO:0031953
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q99653 (/ISS)
Positive regulation of protein transport GO:0051222
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Regulation of intracellular pH GO:0051453
Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Positive regulation of protein glycosylation GO:0060050
Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Cellular response to acidic pH GO:0071468
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q99653 (/ISS)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q99653 (/ISS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P61023 (/IDA) Q5ZM44 (/IDA)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
1 P61023 (/IDA)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P61023 (/IDA)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P61023 (/IDA)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
1 P61023 (/IDA)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q99653 (/TAS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q99653 (/TAS)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q99653 (/IDA)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 P61022 (/ISO)
Calcium ion regulated exocytosis GO:0017156
The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
1 P61023 (/IDA)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 P61023 (/TAS)
Membrane docking GO:0022406
The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.
1 P61023 (/IDA)
Hyaluronan catabolic process GO:0030214
The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
1 Q99653 (/TAS)
Cytoplasmic microtubule organization GO:0031122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
1 P61023 (/IDA)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 P61023 (/IDA)
Negative regulation of protein autophosphorylation GO:0031953
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
1 P61023 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q99653 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 P61022 (/ISO)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
1 Q99653 (/IDA)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
1 Q5ZM44 (/IMP)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
1 P61022 (/ISO)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
1 Q99653 (/IDA)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
1 P61022 (/ISO)
Positive regulation of protein transport GO:0051222
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P61023 (/IDA)
Protein oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P61023 (/IDA)
Regulation of intracellular pH GO:0051453
Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
1 Q99653 (/IDA)
Regulation of intracellular pH GO:0051453
Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
1 P61022 (/ISO)
Positive regulation of protein glycosylation GO:0060050
Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
1 P61023 (/IDA)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 P61023 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 P61023 (/IDA)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
1 Q99653 (/IDA)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
1 P61022 (/ISO)
Cellular response to acidic pH GO:0071468
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 Q5ZM44 (/IDA)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q5ZM44 (/IDA)
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
1 Q99653 (/IMP)
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
1 P61022 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P61022 (/ISS) P61023 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
5 P61022 (/ISS) Q3SYS6 (/ISS) Q5R7F0 (/ISS) Q5ZM44 (/ISS) Q99653 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P61023 (/IDA) Q99653 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 P61023 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P61023 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P61023 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P61023 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P61023 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P61022 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q99653 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q99653 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P61022 (/ISO)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
1 P61023 (/IDA)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 P61023 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q99653 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P61022 (/ISO)