The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14694: Phosphoinositide phospholipase C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 P13217 (/IMP)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 P13217 (/TAS)
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
1 P13217 (/TAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 P13217 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P13217 (/IPI)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
1 P13217 (/IMP)
Mucosal immune response GO:0002385
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
1 P13217 (/IMP)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P13217 (/TAS)
Diacylglycerol biosynthetic process GO:0006651
The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
1 P13217 (/TAS)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
1 P13217 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
1 P13217 (/TAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 P13217 (/IMP)
Light-induced release of internally sequestered calcium ion GO:0008377
The process in which the detection of light triggers the release of internally sequestered calcium ions.
1 P13217 (/TAS)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P13217 (/TAS)
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
1 P13217 (/IMP)
Rhodopsin mediated signaling pathway GO:0016056
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
1 P13217 (/IMP)
Deactivation of rhodopsin mediated signaling GO:0016059
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
1 P13217 (/IDA)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 P13217 (/TAS)
Thermotaxis GO:0043052
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
1 P13217 (/IMP)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
1 P13217 (/IGI)
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
1 P13217 (/IMP)
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 P13217 (/IMP)
Negative regulation of compound eye retinal cell programmed cell death GO:0046673
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
1 P13217 (/IMP)
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
1 P13217 (/TAS)
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
1 P13217 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
1 P13217 (/IPI)
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
1 P13217 (/TAS)
Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
1 P13217 (/IDA)