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CATH Superfamily 1.10.20.10

Histone, subunit A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Histone, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 92: Histone H3

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[Histone H3]-lysine-36 demethylase. [EC: 1.14.11.27]
(1) Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). (2) Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
  • Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36.
  • Lysine residues exist in three methylation states (mono-, di- and trimethylated).
  • The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36.
  • It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.
 8 A0A096XEG8 A0A096XEH8 A0A096XEI3 A0A096XEL4 A0A0G2QTY6 A0A142F321 A0A173FEE5 G3CI39
Histone-lysine N-methyltransferase. [EC: 2.1.1.43]
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
    		 3 A0A161BZD1 C8YNK6 D0VTB2
    Histone acetyltransferase. [EC: 2.3.1.48]
    Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
    • A group of enzymes acetylating histones.
    • Several of the enzymes can also acetylate lysines in other proteins.
    		 3 A0A0P0HPD6 A0A0P0I0A0 A0A0U5NK79
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