The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"main proteinase (3clpro) structure, domain 3
".
FunFam 41: Replicase polyprotein 1a
There are 5 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
Ubiquitinyl hydrolase 1.
[EC: 3.4.19.12]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
|
81 |
A7J8L2
A7J8L3
B8Q8Q1
B8Q8Q2
C4P6Q5
C4P6Q6
D3KDM3
D3KDM4
F1CNY5
K9N638 (71 more...) |
SARS coronavirus main proteinase.
[EC: 3.4.22.69]
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
|
69 |
A7J8L2
A7J8L3
B8Q8Q1
B8Q8Q2
C4P6Q5
C4P6Q6
D3KDM3
D3KDM4
K9N638
K9N7C7 (59 more...) |
RNA helicase.
[EC: 3.6.4.13]
ATP + H(2)O = ADP + phosphate.
|
43 |
A7J8L2
B8Q8Q1
C4P6Q5
D3KDM3
K9N7C7
P0C6V9
P0C6W0
P0C6W1
P0C6W2
P0C6W3 (33 more...) |
DNA helicase.
[EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
|
43 |
A7J8L2
B8Q8Q1
C4P6Q5
D3KDM3
K9N7C7
P0C6V9
P0C6W0
P0C6W1
P0C6W2
P0C6W3 (33 more...) |
RNA-directed RNA polymerase.
[EC: 2.7.7.48]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
|
43 |
A7J8L2
B8Q8Q1
C4P6Q5
D3KDM3
K9N7C7
P0C6V9
P0C6W0
P0C6W1
P0C6W2
P0C6W3 (33 more...) |