The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Transcription Factor, Ets-1
".
FunFam 4816: Ephrin type-A receptor 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
11 |
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6RGK7 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
Q03137 (/ISS)
(1 more) |
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
|
11 |
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6RGK7 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
Q03137 (/ISS)
(1 more) |
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) Q07496 (/ISS) Q91694 (/ISS) Q91845 (/ISS) |
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) Q07496 (/ISS) Q91694 (/ISS) Q91845 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | D3ZZK3 (/IPI) P54764 (/IPI) Q03137 (/IPI) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | P54764 (/IDA) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q03137 (/ISO) |
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
|
1 | Q03137 (/IMP) |
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
1 | Q03137 (/IDA) |
PH domain binding GO:0042731
Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
|
1 | P54764 (/IPI) |
PH domain binding GO:0042731
Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
|
1 | Q03137 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q03137 (/IPI) |
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
|
1 | D3ZZK3 (/IDA) |
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
|
1 | P54764 (/IDA) |
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
|
1 | Q03137 (/ISO) |
There are 38 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
11 |
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6RGK7 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
Q03137 (/ISS)
(1 more) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
11 |
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6RGK7 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
Q03137 (/ISS)
(1 more) |
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
|
11 |
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6RGK7 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
Q03137 (/ISS)
(1 more) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) Q07496 (/ISS) Q91694 (/ISS) Q91845 (/ISS) |
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
3 | P54764 (/TAS) Q03137 (/TAS) Q07496 (/TAS) |
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Corticospinal tract morphogenesis GO:0021957
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
2 | D3ZZK3 (/IDA) Q03137 (/IDA) |
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
2 | D3ZZK3 (/IMP) Q03137 (/IMP) |
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Regulation of astrocyte differentiation GO:0048710
Any process that modulates the frequency, rate or extent of astrocyte differentiation.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
|
2 | P54764 (/ISS) Q07496 (/ISS) |
Fasciculation of motor neuron axon GO:0097156
The collection of motor neuron axons into a bundle of rods, known as a fascicle.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q07496 (/NAS) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q03137 (/IGI) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q03137 (/IMP) |
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
|
1 | Q03137 (/IMP) |
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q03137 (/IMP) |
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
|
1 | D3ZZK3 (/IMP) |
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
1 | P54764 (/IDA) |
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
1 | Q03137 (/ISO) |
Corticospinal tract morphogenesis GO:0021957
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
|
1 | Q03137 (/IMP) |
Segmentation GO:0035282
The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
|
1 | Q07496 (/NAS) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q03137 (/IMP) |
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | Q03137 (/IDA) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | P54764 (/IDA) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | Q03137 (/ISO) |
Regulation of astrocyte differentiation GO:0048710
Any process that modulates the frequency, rate or extent of astrocyte differentiation.
|
1 | Q03137 (/IMP) |
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
1 | Q03137 (/IMP) |
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
|
1 | D3ZZK3 (/IMP) |
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q03137 (/IMP) |
Nephric duct morphogenesis GO:0072178
The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.
|
1 | Q03137 (/IGI) |
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
|
1 | Q03137 (/IMP) |
Fasciculation of motor neuron axon GO:0097156
The collection of motor neuron axons into a bundle of rods, known as a fascicle.
|
1 | Q03137 (/IMP) |
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
|
1 | P54764 (/IDA) |
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
|
1 | Q03137 (/ISO) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
11 |
D2HRP3 (/ISS)
E1BER5 (/ISS)
F6RGK7 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
P54764 (/ISS)
Q03137 (/ISS)
(1 more) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) Q07496 (/ISS) Q91694 (/ISS) Q91845 (/ISS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P54764 (/ISS) Q07496 (/ISS) Q91694 (/ISS) Q91845 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P54764 (/TAS) Q03137 (/TAS) Q07496 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | D3ZZK3 (/IDA) Q03137 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
2 | D3ZZK3 (/IDA) Q03137 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
2 | D3ZZK3 (/ISS) P54764 (/ISS) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
2 | D3ZZK3 (/IDA) P54764 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | D3ZZK3 (/IDA) |
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
1 | D3ZZK3 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | D3ZZK3 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | D3ZZK3 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | D3ZZK3 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | D3ZZK3 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | D3ZZK3 (/IDA) |
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | D3ZZK3 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q03137 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
1 | D3ZZK3 (/IDA) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q03137 (/IDA) |
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
|
1 | D3ZZK3 (/IDA) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | Q03137 (/ISO) |
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
1 | P54764 (/IDA) |
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
1 | Q03137 (/ISO) |
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | D3ZZK3 (/IDA) |
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
|
1 | D3ZZK3 (/IDA) |
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
|
1 | D3ZZK3 (/IDA) |
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
1 | D3ZZK3 (/IDA) |