The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Di-copper center containing domain from catechol oxidase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 269: Tyrosinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Monophenol monooxygenase activity GO:0004503
Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
2 P14679 (/IDA) Q0MVP0 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P11344 (/IPI) P14679 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P11344 (/IDA) Q0MVP0 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P14679 (/ISS) Q9BDE0 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P14679 (/ISS) Q9BDE0 (/ISS)
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
1 P14679 (/TAS)
Monophenol monooxygenase activity GO:0004503
Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
1 D4A9G4 (/IMP)
Monophenol monooxygenase activity GO:0004503
Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
1 P11344 (/ISO)
Monophenol monooxygenase activity GO:0004503
Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
1 Q04604 (/ISS)
Monophenol monooxygenase activity GO:0004503
Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
1 P11344 (/TAS)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 Q0MVP0 (/IDA)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 P14679 (/IMP)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 P11344 (/ISO)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 Q04604 (/ISS)
L-DOPA monooxygenase activity GO:0036263
Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone.
1 Q0MVP0 (/IDA)
L-DOPA monooxygenase activity GO:0036263
Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone.
1 Q04604 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P11344 (/IDA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
2 D4A9G4 (/TAS) P14679 (/TAS)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
2 D4A9G4 (/IMP) P11344 (/IMP)
Melanin biosynthetic process from tyrosine GO:0006583
The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
1 Q0MVP0 (/IDA)
Melanin biosynthetic process from tyrosine GO:0006583
The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
1 Q04604 (/ISS)
Melanin biosynthetic process from tyrosine GO:0006583
The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
1 P14679 (/TAS)
Eye pigment biosynthetic process GO:0006726
The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
1 P14679 (/TAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 P14679 (/TAS)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P11344 (/IMP)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 D4A9G4 (/IEP)
Response to vitamin D GO:0033280
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
1 D4A9G4 (/IEP)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
1 P14679 (/IDA)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
1 P11344 (/IMP)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
1 P11344 (/ISO)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
1 P11344 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q0MVP0 (/IDA)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 D4A9G4 (/IEP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
5 P14679 (/ISS) P55024 (/ISS) Q04604 (/ISS) Q08410 (/ISS) Q9BDE0 (/ISS)
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
2 P11344 (/IDA) Q0MVP0 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 L8B082 (/IDA) P14679 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 D4A9G4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P14679 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P11344 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P14679 (/TAS)
Golgi-associated vesicle GO:0005798
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
1 P14679 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 D4A9G4 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P11344 (/TAS)
Melanosome membrane GO:0033162
The lipid bilayer surrounding a melanosome.
1 P14679 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P11344 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P14679 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P11344 (/ISO)
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