The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Di-copper center containing domain from catechol oxidase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2181: 5,6-dihydroxyindole-2-carboxylic acid oxidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dopachrome isomerase activity GO:0004167
Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
3 P40126 (/ISS) Q4R1H1 (/ISS) Q95119 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P17643 (/ISS) Q8MIU0 (/ISS) Q8WN57 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 P17643 (/ISS) Q8MIU0 (/ISS) Q8WN57 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P07147 (/IPI) P17643 (/IPI)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
2 P17643 (/TAS) P40126 (/TAS)
Dopachrome isomerase activity GO:0004167
Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
1 P29812 (/IDA)
Dopachrome isomerase activity GO:0004167
Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
1 P29812 (/IMP)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 P40126 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P07147 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P07147 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Melanin biosynthetic process from tyrosine GO:0006583
The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
3 P40126 (/ISS) Q4R1H1 (/ISS) Q95119 (/ISS)
Melanin biosynthetic process from tyrosine GO:0006583
The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
2 P07147 (/TAS) P40126 (/TAS)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
2 F1QEC9 (/IGI) Q6DGE4 (/IGI)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
2 F1QEC9 (/IMP) P07147 (/IMP)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
2 P17643 (/TAS) P40126 (/TAS)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
2 F1QEC9 (/IGI) Q6DGE4 (/IGI)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
2 P07147 (/IMP) P29812 (/IMP)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 P29812 (/IMP)
Melanin metabolic process GO:0006582
The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
1 P07147 (/IMP)
Melanin biosynthetic process from tyrosine GO:0006583
The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.
1 P29812 (/IDA)
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
1 P40126 (/TAS)
Ventricular zone neuroblast division GO:0021847
The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.
1 P29812 (/IMP)
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
1 P07147 (/IMP)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
1 P29812 (/IMP)
Acetoacetic acid metabolic process GO:0043438
The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.
1 P07147 (/IMP)
Positive regulation of melanin biosynthetic process GO:0048023
Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
1 P07147 (/IGI)
Positive regulation of melanin biosynthetic process GO:0048023
Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
1 P17643 (/IMP)
Positive regulation of melanin biosynthetic process GO:0048023
Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
1 P07147 (/ISO)
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
1 P29812 (/IMP)
Cell development GO:0048468
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 P29812 (/IMP)
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q6DGE4 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
11 O57405 (/ISS) O93505 (/ISS) P17643 (/ISS) P40126 (/ISS) P54834 (/ISS) P55027 (/ISS) P55028 (/ISS) Q4R1H1 (/ISS) Q8MIU0 (/ISS) Q8WN57 (/ISS)
(1 more)
Melanosome membrane GO:0033162
The lipid bilayer surrounding a melanosome.
5 O57405 (/ISS) P17643 (/ISS) P55027 (/ISS) P55028 (/ISS) Q8WN57 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P40126 (/ISS) Q4R1H1 (/ISS) Q95119 (/ISS)
Melanosome membrane GO:0033162
The lipid bilayer surrounding a melanosome.
2 P17643 (/TAS) P40126 (/TAS)
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
2 P07147 (/IDA) P29812 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P29812 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P29812 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 P17643 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 P07147 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P40126 (/TAS)
Clathrin-coated endocytic vesicle membrane GO:0030669
The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
1 P17643 (/IDA)
Clathrin-coated endocytic vesicle membrane GO:0030669
The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
1 P07147 (/ISO)
Melanosome membrane GO:0033162
The lipid bilayer surrounding a melanosome.
1 P07147 (/IDA)