View in Gene3D

CATH Superfamily 1.10.1270.20

tRNA(m1g37)methyltransferase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
tRNA(m1g37)methyltransferase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1640: tRNA (guanine-N(1)-)-methyltransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanine(37)-N(1))-methyltransferase. [EC: 2.1.1.228]
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
  • This enzyme is important for the maintenance of the correct reading frame during translation.
  • Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37.
  • Formerly EC 2.1.1.31.
 69 A0A022SU98 A0A098MZU2 A0A0C5X3H9 A0A0E2B0J0 A0A0E2BJN3 A0A0E2CJC1 A0A0E2CWX1 A0A0E2D3X4 A0A0E2EB51 A0A0E2IC74
(59 more...)