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CATH Superfamily 1.10.1160.10

Glutamyl-trna Synthetase; Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Glutamyl-trna Synthetase; Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2859: Glutamate--tRNA ligase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutamate--tRNA ligase. [EC: 6.1.1.17]
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
    		 396 A0A024H1G2 A0A031G0B3 A0A031GQ70 A0A031H186 A0A031IU16 A0A045H9J8 A0A049DJQ8 A0A060JMQ5 A0A069JH68 A0A076JH26
    (386 more...)
    Glutamate--tRNA(Gln) ligase. [EC: 6.1.1.24]
    ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx).
    • When this enzyme acts on tRNA(Glu), it catalyzes the same reaction as EC 6.1.1.17.
    • It has, however, diminished discrimination, so that it can also form glutamate-tRNA(Gln).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA(1)(Gln) (UUG anticodon) and tRNA(Glu) (UUC anticodon) but not tRNA(2)(Gln) (CUG anticodon).
    • The ability of this enzyme to recognize both tRNA(Glu) and one of the tRNA(Gln) isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2- thiouridine).
    • The glutamyl-tRNA(Gln) is not used in protein synthesis until it is converted by EC 6.3.5.7 into glutaminyl-tRNA(Gln).
    		 24 A0A083XTI6 A0A0A0UE85 A0A0A1GPS4 A0A0H5D2S3 A0A0K3BB16 A0A0M0VKY1 A0A0N7H8H1 A0A1B1NGS4 A0A1D7W5S5 B3DU87
    (14 more...)
    DNA-directed RNA polymerase. [EC: 2.7.7.6]
    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
    • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
    • Can initiate a chain de novo.
    • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
    • See also EC 2.7.7.19 and EC 2.7.7.48.
    		 2 A0A0C1DTP8 A0A0Q5IZ35
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