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CATH Superfamily 1.10.1160.10

Glutamyl-trna Synthetase; Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Glutamyl-trna Synthetase; Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2827: Glutamate--tRNA ligase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutamate--tRNA ligase. [EC: 6.1.1.17]
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
    		 84 A0A068N0H1 A0A073CF00 A0A089P902 A0A089QIU6 A0A0A1VST2 A0A0A1ZJK9 A0A0A1ZSK5 A0A0A2A8H2 A0A0A2AAG4 A0A0A2AJ88
    (74 more...)
    Glutamate--tRNA(Gln) ligase. [EC: 6.1.1.24]
    ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx).
    • When this enzyme acts on tRNA(Glu), it catalyzes the same reaction as EC 6.1.1.17.
    • It has, however, diminished discrimination, so that it can also form glutamate-tRNA(Gln).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA(1)(Gln) (UUG anticodon) and tRNA(Glu) (UUC anticodon) but not tRNA(2)(Gln) (CUG anticodon).
    • The ability of this enzyme to recognize both tRNA(Glu) and one of the tRNA(Gln) isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2- thiouridine).
    • The glutamyl-tRNA(Gln) is not used in protein synthesis until it is converted by EC 6.3.5.7 into glutaminyl-tRNA(Gln).
    		 25 A0A068N0H1 A0A089P902 A0A089QIU6 A0A0A1ZJK9 A0A0A1ZSK5 A0A0A2A8H2 A0A0A2AAG4 A0A0A2AJ88 A0A0A2B0T2 A0A0A2B2L1
    (15 more...)
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