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CATH Superfamily 1.10.1060.10

Alpha-helical ferredoxin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Alpha-helical ferredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2770: Dihydropyrimidine dehydrogenase subunit A

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydrouracil dehydrogenase (NAD(+)). [EC: 1.3.1.1]
(1) 5,6-dihydrouracil + NAD(+) = uracil + NADH. (2) 5,6-dihydrothymine + NAD(+) = thymine + NADH.
  • The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth.
  • Since then the enzyme was found in additional organisms including Alcaligenes eutrophus, Pseudomonas strains and Escherichia coli.
 152 A0A017IDT5 A0A024L1V6 A0A026UL43 A0A027U5B1 A0A028A000 A0A028DL80 A0A029HSZ9 A0A029IQR9 A0A029KMU0 A0A029LJG2
(142 more...)
Dihydropyrimidine dehydrogenase (NADP(+)). [EC: 1.3.1.2]
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
  • Also acts on dihydrothymine.
 8 A0A066T035 A0A090NBM5 A0A0A6ZVN4 A0A125XH44 A0A192C9L8 A0A1L8ZZD6 Q32EM7 W9AHM5
Glutamate synthase (NADPH). [EC: 1.4.1.13]
2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH.
  • The reaction takes place in the opposite direction.
  • The protein is composed of two subunits, alpha and beta.
  • The alpha subunit is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.4).
  • The beta subunit transfers electrons to the cosubstrate.
  • The NH(3) is channeled through a 31 A channel in the active protein.
  • In the absence of the beta subunit, coupling between the two domains of the alpha subunit is compromised and some ammonium can be produced.
  • In the intact alpha-beta complex, ammonia production only takes place as part of the overall reaction.
  • Formerly EC 2.6.1.53.
 6 A0A0D6IXJ3 A0A0E2LJP4 A0A0G3IZB6 A0A0H2Z169 B7MF58 Q1R9S7
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