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CATH Superfamily 1.10.1060.10

Alpha-helical ferredoxin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Alpha-helical ferredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10256: Probable dihydropyrimidine dehydrogenase [NADP(+)]

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydropyrimidine dehydrogenase (NADP(+)). [EC: 1.3.1.2]
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
  • Also acts on dihydrothymine.
 12 A8XKG6 E0VSW7 O89000 Q12882 Q18164 Q28007 Q28943 Q55FT1 Q5R895 Q6NYG8
(2 more...)
Dihydroorotate dehydrogenase (quinone). [EC: 1.3.5.2]
(S)-dihydroorotate + a quinone = orotate + a quinol.
  • This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
  • The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane.
  • The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates.
  • Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not.
  • Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • Formerly EC 1.3.99.11.
 10 A0A0R3NZ50 A0A0R3P3X8 B3MZM3 B3NUF8 B4L397 B4M3S4 B4NDZ2 B4PZV8 Q29IG0 Q9W374
Dihydrouracil dehydrogenase (NAD(+)). [EC: 1.3.1.1]
(1) 5,6-dihydrouracil + NAD(+) = uracil + NADH. (2) 5,6-dihydrothymine + NAD(+) = thymine + NADH.
  • The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth.
  • Since then the enzyme was found in additional organisms including Alcaligenes eutrophus, Pseudomonas strains and Escherichia coli.
 1 Q9W374
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