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CATH Superfamily 1.10.1040.10

N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6571: 3-hydroxyisobutyrate dehydrogenase family protein

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sulfolactaldehyde 3-reductase. [EC: 1.1.1.373]
2,3-dihydroxypropane-1-sulfonate + NAD(+) = 2-hydroxy-3-oxopropane-1- sulfonate + NADH.
  • The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea.
 407 A0A023V776 A0A024KLN1 A0A024L6L5 A0A026UZR7 A0A027TPT9 A0A027ZWH0 A0A028E566 A0A029HEQ0 A0A029IHW5 A0A029K256
(397 more...)
2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
    		 63 A0A027TPT9 A0A027ZWH0 A0A028E566 A0A029K256 A0A066Q5Q8 A0A069XRU2 A0A070SRF2 A0A080EYS4 A0A0A0FBD0 A0A0A8ULQ4
    (53 more...)
    3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
    3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
      		 4 A0A084TBA2 A0A1A7UPL4 A0A1J4R1P5 A6CWA0
      2-hydroxymethylglutarate dehydrogenase. [EC: 1.1.1.291]
      (S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.
      • NADP(+) cannot replace NAD(+).
      • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
      • Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
      		 1 A0A1N6MA71