View in Gene3D

CATH Superfamily 1.10.1040.10

N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 17612: Alanopine dehydrogenase 2

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-octopine dehydrogenase. [EC: 1.5.1.11]
N(2)-(D-1-carboxyethyl)-L-arginine + NAD(+) + H(2)O = L-arginine + pyruvate + NADH.
  • Also acts, in the reverse direction, on L-ornithine, L-lysine and L-histidine.
 14 A0A109CRN9 M1FBU6 M1FHV2 M1FK93 P0A394 P0A395 P94210 Q7BLS2 Q8N0P0 Q9BHK4
(4 more...)
D-lysopine dehydrogenase. [EC: 1.5.1.16]
N(2)-(D-1-carboxyethyl)-L-lysine + NADP(+) + H(2)O = L-lysine + pyruvate + NADPH.
  • In the reverse reaction, a number of L-amino acids can act instead of L-lysine, and 2-oxobutanoate and, to a lesser extent, glyoxylate can act instead of pyruvate.
 6 A0A109CRN9 P0A394 P0A395 P94210 Q7BLS2 W8FU90
Strombine dehydrogenase. [EC: 1.5.1.22]
N-(carboxymethyl)-D-alanine + NAD(+) + H(2)O = glycine + pyruvate + NADH.
  • Catalyzes the reaction of EC 1.5.1.17, more slowly.
  • Does not act on L-strombine.
 4 B5D5P1 B5D5P3 B5D5Q0 B7FBJ2
Alanopine dehydrogenase. [EC: 1.5.1.17]
2,2'-iminodipropanoate + NAD(+) + H(2)O = L-alanine + pyruvate + NADH.
  • In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine, or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22).
 4 B5D5P2 B5D5P4 B6YPR6 I7HP94
Opine dehydrogenase. [EC: 1.5.1.28]
(2S)-2-((1-(R)-carboxyethyl)amino)pentanoate + NAD(+) + H(2)O = L-2- aminopentanoic acid + pyruvate + NADH.
  • In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine.
  • Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate.
  • In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor.
  • They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine.
  • The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate.
 1 Q44297
Tauropine dehydrogenase. [EC: 1.5.1.23]
Tauropine + NAD(+) + H(2)O = taurine + pyruvate + NADH.
  • In the reverse reaction, alanine can act instead of taurine, more slowly, and 2-oxobutanoate and 2-oxopentanoate can act instead of pyruvate.
 1 Q8T882