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CATH Superfamily 1.10.1040.10

N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17579: Probable 3-hydroxyisobutyrate dehydrogenase, mitoc...

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
    		 7632 A0A009GSB7 A0A009GSB7 A0A009H0T9 A0A009H0T9 A0A009HLU7 A0A009HLU7 A0A009I6D5 A0A009I6D5 A0A009J5M3 A0A009J5M3
    (7622 more...)
    2-hydroxymethylglutarate dehydrogenase. [EC: 1.1.1.291]
    (S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.
    • NADP(+) cannot replace NAD(+).
    • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
    • Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
    		 74 A0A058YWW2 A0A058YWW2 A0A0C6NZP3 A0A0C6NZP3 A0A0E8FHD9 A0A0E8FHD9 A0A0E8FQB6 A0A0E8FQB6 A0A0H3J625 A0A0H3J625
    (64 more...)
    2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
    D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
      		 34 A0A0T9EXE4 A0A0T9EXE4 A0A0U1KY73 A0A0U1KY73 A0A1D7TIR2 A0A1D7TIR2 A0A1M4M2W2 A0A1M4M2W2 A1AR34 A1AR34
      (24 more...)
      Succinic semialdehyde reductase. [EC: 1.1.1.n11]
      4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
        		 8 A0A178VK60 A0A178VK60 A0A178WM95 A0A178WM95 F4I907 F4I907 Q9LSV0 Q9LSV0
        Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
        Glycolate + NADP(+) = glyoxylate + NADPH.
        • Also reduces hydroxypyruvate to glycerate.
        • Has some affinity for NAD(+).
        		 8 A0A178VK60 A0A178VK60 A0A178WM95 A0A178WM95 F4I907 F4I907 Q9LSV0 Q9LSV0
        Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). [EC: 1.1.1.44]
        6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
        • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
        • Highly specific for NADP(+).
        • Cf. EC 1.1.1.343.
        		 8 A0A0J9R0H6 A0A0J9R0H6 A0A0J9TK12 A0A0J9TK12 A0A0Q9W7W0 A0A0Q9W7W0 A0A0R3NS77 A0A0R3NS77
        Succinate-semialdehyde dehydrogenase (NADP(+)). [EC: 1.2.1.79]
        Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
        • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
        • It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+).
        • The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
        		 4 A0A1C8M582 A0A1C8M582 A0A1C8M593 A0A1C8M593
        L-serine 3-dehydrogenase (NAD(+)). [EC: 1.1.1.387]
        L-serine + NAD(+) = 2-aminoacetaldehyde + CO(2) + NADH.
        • The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103).
        • The enzyme has only very low activity with NADP(+) (cf. EC 1.1.1.276).
        		 2 Q9I5I6 Q9I5I6
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