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CATH Superfamily 1.10.1040.10

N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17553: NAD binding domain of 6-phosphogluconate dehydroge...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
    		 358 A0A026V9F6 A0A026V9F6 A0A027U7P7 A0A027U7P7 A0A028A6M1 A0A028A6M1 A0A028EBN7 A0A028EBN7 A0A029LF49 A0A029LF49
    (348 more...)
    3-hydroxybutyrate dehydrogenase. [EC: 1.1.1.30]
    (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
    • Also oxidizes other 3-hydroxymonocarboxylic acids.
    		 338 A0A026V9F6 A0A026V9F6 A0A027U7P7 A0A027U7P7 A0A028A6M1 A0A028A6M1 A0A028EBN7 A0A028EBN7 A0A029LF49 A0A029LF49
    (328 more...)
    3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
    3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
      		 176 A0A023VHR8 A0A023VHR8 A0A031IPM2 A0A031IPM2 A0A077SLF7 A0A077SLF7 A0A088FNJ7 A0A088FNJ7 A0A089NMI2 A0A089NMI2
      (166 more...)
      2-hydroxymethylglutarate dehydrogenase. [EC: 1.1.1.291]
      (S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.
      • NADP(+) cannot replace NAD(+).
      • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
      • Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
      		 160 A0A011QJ97 A0A011QJ97 A0A023VHR8 A0A023VHR8 A0A066PCG9 A0A066PCG9 A0A077SLF7 A0A077SLF7 A0A080LUN0 A0A080LUN0
      (150 more...)
      Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). [EC: 1.1.1.44]
      6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
      • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
      • Highly specific for NADP(+).
      • Cf. EC 1.1.1.343.
      		 12 A0A085HFT3 A0A085HFT3 A0A0N0IB52 A0A0N0IB52 A0A1B7JRG3 A0A1B7JRG3 A0A1L9EU39 A0A1L9EU39 D8IUH1 D8IUH1
      (2 more...)
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