The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10079: 6-phosphogluconate dehydrogenase NAD-binding domai...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
    24 A0A0G3VCF1 A0A0K0I4I2 A0A0K6JWP9 A0A0K6KJN7 A0A0K6KL48 A0A0K6LLB0 A0A0K6ME95 A0A0M0L197 A0A0M2EDK9 A0A0T8PXN5
    (14 more...)
    3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
    3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
      11 A0A0A0TW65 A0A0E1LR00 A0A0G3VCF1 A0A0U0C6N9 A0A1A0C8Q7 A0A1A5VJI7 A0A1D9PIP6 A7Z409 E1USL0 I2C4B7
      (1 more...)
      Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). [EC: 1.1.1.44]
      6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
      • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
      • Highly specific for NADP(+).
      • Cf. EC 1.1.1.343.
      1 M5R253
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