The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Arf Nucleotide-binding Site Opener,domain 2
".
FunFam 916: PH and SEC7 domain-containing protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
4 | F1MUS9 (/ISS) G5EET6 (/ISS) Q5DTT2 (/ISS) Q9ESQ7 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | A5PKW4 (/IPI) G5EET6 (/IPI) Q5DTT2 (/IPI) Q8NDX1 (/IPI) |
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
2 | A5PKW4 (/IDA) Q2PFD7 (/IDA) |
Guanine nucleotide transmembrane transporter activity GO:0001409
Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other.
|
1 | Q9ESQ7 (/TAS) |
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | A5PKW4 (/NAS) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of ARF protein signal transduction GO:0032012
Any process that modulates the frequency, rate or extent of ARF protein signal transduction.
|
6 | A8JR81 (/IC) A8JR82 (/IC) E1JIT7 (/IC) E2QD55 (/IC) E2QD56 (/IC) Q8MRV5 (/IC) |
Adult chitin-containing cuticle pigmentation GO:0048085
Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster.
|
6 | A8JR81 (/IMP) A8JR82 (/IMP) E1JIT7 (/IMP) E2QD55 (/IMP) E2QD56 (/IMP) Q8MRV5 (/IMP) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | A0A0R4IAG2 (/IMP) E7EZJ7 (/IMP) |
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
|
2 | A0A0R4IAG2 (/IMP) E7EZJ7 (/IMP) |
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
2 | A0A0R4IAG2 (/IMP) E7EZJ7 (/IMP) |
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
|
1 | A8JR81 (/IGI) |
Microtubule depolymerization GO:0007019
The removal of tubulin heterodimers from one or both ends of a microtubule.
|
1 | G5EET6 (/IMP) |
Mitotic nuclear envelope disassembly GO:0007077
The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.
|
1 | G5EET6 (/IMP) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | A5PKW4 (/NAS) |
Guanine transport GO:0015854
The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9ESQ7 (/TAS) |
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | Q9ESQ7 (/IEP) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q5DTT2 (/IDA) |
ARF protein signal transduction GO:0032011
A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state.
|
1 | Q2PFD7 (/IC) |
Regulation of mitotic centrosome separation GO:0046602
Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.
|
1 | G5EET6 (/IMP) |
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | G5EET6 (/IDA) |
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
1 | G5EET6 (/IMP) |
Negative regulation of axon extension involved in regeneration GO:0048692
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration.
|
1 | G5EET6 (/IMP) |
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
1 | G5EET6 (/IDA) |
Negative regulation of mitotic spindle elongation GO:1902845
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation.
|
1 | G5EET6 (/IMP) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
6 | F1MUS9 (/ISS) Q5DTT2 (/ISS) Q8BLR5 (/ISS) Q9BQI7 (/ISS) Q9ESQ7 (/ISS) Q9NYI0 (/ISS) |
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
|
4 | F1MUS9 (/ISS) Q5DTT2 (/ISS) Q9BQI7 (/ISS) Q9ESQ7 (/ISS) |
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
4 | A5PKW4 (/IDA) Q2PFD7 (/IDA) Q6P1I6 (/IDA) Q8NDX1 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q2PFD7 (/IDA) Q8NDX1 (/IDA) |
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
|
2 | A5PKW4 (/IDA) Q6P1I6 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | G5EET6 (/IDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | G5EET6 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | Q5DTT2 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8BLR5 (/ISO) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9ESQ7 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q6P1I6 (/IDA) |
Microtubule minus-end GO:0036449
The end of a microtubule that does not preferentially grow (polymerize).
|
1 | G5EET6 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q6P1I6 (/IDA) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | Q5DTT2 (/IDA) |
Extrinsic component of postsynaptic endosome membrane GO:0098999
The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | Q5DTT2 (/IDA) |