The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13566: Homeobox protein Hox-A13

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 P24344 (/ISS) P35453 (/ISS) Q5EU41 (/ISS) Q9IA17 (/ISS)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
3 P24344 (/ISS) Q5EU41 (/ISS) Q9IA17 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 P35453 (/IDA) P70217 (/IDA) Q62424 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
2 P50207 (/IDA) P70217 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P31271 (/TAS) P35453 (/TAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P50207 (/IDA) P70217 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 P70217 (/IDA) Q62424 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P31276 (/IPI) Q62424 (/IPI)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
1 P70217 (/IDA)
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q6W990 (/IDA)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P35453 (/IMP)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P70217 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P70217 (/ISO)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q62424 (/IDA)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
1 D4ACD0 (/IDA)

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prostate gland development GO:0030850
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
3 A0A0G2K5C1 (/IEP) A0A0G2K6K0 (/IEP) D4ACD0 (/IEP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
3 A0A0G2K5C1 (/IEP) A0A0G2K6K0 (/IEP) D4ACD0 (/IEP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P50207 (/IDA) P70217 (/IDA) Q62424 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P24344 (/ISS) Q5EU41 (/ISS) Q9IA17 (/ISS)
Embryonic hindgut morphogenesis GO:0048619
The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase.
3 A0A0G2K5C1 (/IMP) A0A0G2K6K0 (/IMP) D4ACD0 (/IMP)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
2 P31271 (/TAS) P35453 (/TAS)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
2 P50207 (/IMP) Q62424 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
2 P50207 (/IMP) P70217 (/IMP)
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
2 P70217 (/IMP) Q62424 (/IMP)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
2 Q6JIY4 (/IMP) Q6JIY5 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P35453 (/IMP) Q62424 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q6W990 (/IDA)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
1 P70217 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q62424 (/IMP)
Endothelial cell morphogenesis GO:0001886
The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
1 Q62424 (/IMP)
Tissue homeostasis GO:0001894
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
1 Q62424 (/IMP)
Hair follicle development GO:0001942
The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
1 P50207 (/IMP)
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
1 Q62424 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P35453 (/TAS)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P35453 (/TAS)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
1 P35453 (/TAS)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
1 P70217 (/IGI)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
1 P70217 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 P31276 (/TAS)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q62424 (/IMP)
Gland morphogenesis GO:0022612
The process in which the anatomical structures of a gland are generated and organized.
1 P70217 (/IMP)
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
1 P70217 (/IMP)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
1 Q62424 (/IMP)
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
1 P70217 (/IGI)
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
1 P70217 (/IMP)
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
1 Q62424 (/IMP)
Nail development GO:0035878
The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.
1 P50207 (/IMP)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 P70217 (/IMP)
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
1 P70217 (/IGI)
Tongue morphogenesis GO:0043587
The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.
1 P50207 (/IMP)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
1 Q62424 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P70217 (/ISO)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
1 Q62424 (/IMP)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
1 Q62424 (/IMP)
Branching involved in prostate gland morphogenesis GO:0060442
The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
1 Q62424 (/IMP)
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527
The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.
1 P70217 (/IGI)
Morphogenesis of an epithelial fold GO:0060571
The morphogenetic process in which an epithelial sheet bends along a linear axis.
1 P70217 (/IMP)
Branch elongation of an epithelium GO:0060602
The growth process in which a branch increases in length from its base to its tip.
1 P70217 (/IMP)
Regulation of branching involved in prostate gland morphogenesis GO:0060687
Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
1 P70217 (/IMP)
Endothelial cell fate specification GO:0060847
The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 Q62424 (/IMP)
Positive regulation of mesenchymal cell apoptotic process GO:2001055
Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.
1 Q62424 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 D4ACD0 (/IDA) P35453 (/IDA) P50207 (/IDA) P70217 (/IDA) Q62424 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P70217 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P31271 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q62424 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 P31271 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 Q62424 (/ISO)