The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 124903: Protein phosphatase Slingshot homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 Q6NN85 (/IDA) Q8WYL5 (/IDA)
Chitin synthase activity GO:0004100
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine +
2 C8V173 (/RCA) G5EB74 (/RCA)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2 Q6NN85 (/IDA) Q8WYL5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O74503 (/IPI) Q8WYL5 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 C8V173 (/IMP)
Chitin synthase activity GO:0004100
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine +
1 G5EB74 (/IMP)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
1 Q8WYL5 (/IMP)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q6NN85 (/NAS)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
3 C8V173 (/IMP) G5EB74 (/IMP) Q4X0H6 (/IMP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
3 C8V173 (/IMP) G5EB74 (/IMP) Q4X0H6 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
2 Q6NN85 (/IMP) Q8WYL5 (/IMP)
Chitin biosynthetic process GO:0006031
The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
2 C8V173 (/RCA) G5EB74 (/RCA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 Q6NN85 (/IMP) Q8WYL5 (/IMP)
Cell tip growth GO:0009932
Growth that occurs specifically at the tip of a cell.
2 C8V173 (/IGI) G5EB74 (/IGI)
Cell tip growth GO:0009932
Growth that occurs specifically at the tip of a cell.
2 C8V173 (/IMP) G5EB74 (/IMP)
Conidium formation GO:0048315
The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
2 C8V173 (/IMP) G5EB74 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q6NN85 (/IMP)
Chitin biosynthetic process GO:0006031
The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
1 G5EB74 (/IMP)
Cell wall chitin biosynthetic process GO:0006038
The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells.
1 Q4X0H6 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 Q6NN85 (/NAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 Q6NN85 (/IMP)
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
1 Q6NN85 (/IMP)
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
1 Q6NN85 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
1 Q6NN85 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q8WYL5 (/IMP)
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
1 Q6NN85 (/IMP)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
1 Q6NN85 (/IDA)
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 F1LWM1 (/IMP)
Regulation of cellular protein metabolic process GO:0032268
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
1 Q8WYL5 (/IDA)
Establishment of nucleus localization GO:0040023
The directed movement of the nucleus to a specific location within a cell.
1 Q6NN85 (/IMP)
Asexual sporulation resulting in formation of a cellular spore GO:0043936
The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
1 Q4X0H6 (/IMP)
Positive regulation of transcription from RNA polymerase I promoter GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter.
1 O74503 (/TAS)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
1 Q6NN85 (/IGI)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
1 Q6NN85 (/IGI)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
1 Q6NN85 (/IMP)
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
1 Q8WYL5 (/IDA)
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 G5EB74 (/IEP)
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 G5EB74 (/IMP)
Excitatory chemical synaptic transmission GO:0098976
Synaptic transmission that results in an excitatory postsynaptic potential.
1 F1LWM1 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 F1LWM1 (/IMP)
Positive regulation of AMPA glutamate receptor clustering GO:1904719
Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering.
1 F1LWM1 (/IMP)
Positive regulation of vascular associated smooth muscle cell migration GO:1904754
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.
1 F1LWM1 (/IMP)
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
1 F1LWM1 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hyphal tip GO:0001411
The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
2 C8V173 (/IDA) G5EB74 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 F1LWM1 (/IDA) O74503 (/IDA)
Cell septum GO:0030428
A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
2 C8V173 (/IDA) G5EB74 (/IDA)
RNA polymerase I upstream activating factor complex GO:0000500
A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
1 O74503 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O74503 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8WYL5 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8WYL5 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
1 F1LWM1 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 F1LWM1 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 F1LWM1 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q6NN85 (/IDA)