The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 124740: LAG1 homolog, ceramide synthase 6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sphingosine N-acyltransferase activity GO:0050291
Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.
7 Q1A3B0 (/IDA) Q8C172 (/IDA) Q8N5B7 (/IDA) Q924Z4 (/IDA) Q9D6J1 (/IDA) Q9D6K9 (/IDA) Q9W423 (/IDA)
Sphingosine N-acyltransferase activity GO:0050291
Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.
5 Q6ZMG9 (/TAS) Q8IU89 (/TAS) Q8N5B7 (/TAS) Q96G23 (/TAS) Q9HA82 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q96G23 (/IPI)
Sphingosine N-acyltransferase activity GO:0050291
Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.
1 Q9D6K9 (/ISO)
Sphingosine N-acyltransferase activity GO:0050291
Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.
1 Q9W423 (/ISS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
5 Q1A3B0 (/IDA) Q8C172 (/IDA) Q924Z4 (/IDA) Q9D6J1 (/IDA) Q9D6K9 (/IDA)
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
5 Q6ZMG9 (/TAS) Q8IU89 (/TAS) Q8N5B7 (/TAS) Q96G23 (/TAS) Q9HA82 (/TAS)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
5 Q8C172 (/IDA) Q8N5B7 (/IDA) Q924Z4 (/IDA) Q9D6J1 (/IDA) Q9D6K9 (/IDA)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 Q8IU89 (/IMP) Q9W423 (/IMP)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 Q1A3B0 (/ISO) Q9D6K9 (/ISO)
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
1 Q9W423 (/IMP)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
1 Q8IU89 (/IMP)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
1 Q1A3B0 (/ISO)
SREBP signaling pathway GO:0032933
A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
1 Q9W423 (/IMP)
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
1 Q9W423 (/IMP)
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
1 Q96G23 (/ISS)
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
1 Q9W423 (/IMP)
Negative regulation of Schwann cell migration GO:1900148
Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration.
1 Q96G23 (/ISS)
Negative regulation of Schwann cell proliferation involved in axon regeneration GO:1905045
Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration.
1 Q96G23 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
5 Q6ZMG9 (/TAS) Q8IU89 (/TAS) Q8N5B7 (/TAS) Q96G23 (/TAS) Q9HA82 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 Q8C172 (/IDA) Q9D6J1 (/IDA) Q9D6K9 (/IDA) Q9W423 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q6ZMG9 (/IDA) Q96G23 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8C172 (/ISO) Q924Z4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9W423 (/IDA)
Nuclear inner membrane GO:0005637
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
1 Q9W423 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9W423 (/ISM)