The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 123137: GS homeobox 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P31315 (/IDA) Q9H4S2 (/IDA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
1 P31315 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P31315 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P31315 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P31316 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P31315 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spinal cord association neuron differentiation GO:0021527
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 P31315 (/IGI) P31316 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P31315 (/IDA) Q9H4S2 (/IDA)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
2 P31315 (/IGI) P31316 (/IGI)
Regulation of respiratory gaseous exchange by neurological system process GO:0002087
A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
1 P31316 (/IMP)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
1 P31316 (/IGI)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
1 P31316 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P31316 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P31316 (/IGI)
Subpallium development GO:0021544
The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.
1 P31316 (/IGI)
Hindbrain morphogenesis GO:0021575
The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
1 P31316 (/IMP)
Forebrain dorsal/ventral pattern formation GO:0021798
The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.
1 P31316 (/IMP)
Hypothalamus development GO:0021854
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
1 P31315 (/IMP)
Olfactory bulb interneuron differentiation GO:0021889
The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.
1 P31316 (/IMP)
Telencephalon regionalization GO:0021978
The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.
1 P31316 (/IMP)
Adenohypophysis development GO:0021984
The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
1 P31315 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 P31316 (/IMP)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
1 P31316 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P31315 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P31315 (/ISO)
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
1 P31316 (/IMP)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
1 P31316 (/IMP)
Forebrain morphogenesis GO:0048853
The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 P31316 (/IMP)
Subpallium neuron fate commitment GO:0060163
The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon.
1 P31316 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P31315 (/IC)