The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
Disruption as well as point mutations of the rps19 gene in yeast and human cells affect maturation of the pre-ribosomal RNA (pre-rRNA) and block production of the 40S ribosomal subunits. Specifically, mutations in the rps19 gene are associated with the rare congenital disease Diamond-Blackfan anaemia (DBA). S19 forms a five-helix bundle organised around a central amphipathic alpha-helix, which corresponds to the DBA mutation hot spot.
|Domain clusters (>95% seq id):||3|
|Domain clusters (>35% seq id):||2|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|