The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein S19

The structural domains that comprise this superfamily share the structure of the ribosomal protein S19, a single domain of the 40S small subunit of the eukaryotic ribosome. This superfamily entry includes a number of eukaryotic and archaebacterial ribosomal proteins, such as mammalian S19, Drosophila S19, Ascaris lumbricoides S19g (ALEP-1) and S19s, yeast YS16 (RP55A and RP55B), Aspergillus S16 and Haloarcula marismortui HS12. This protein is esse3a1pntial for yeast viability and for early stages of development in mice. Since there is no homologue of RPS19 in bacteria, for which high-resolution structures of the small ribosomal subunit are available, the structure of RPS19 and its precise location within the 40S subunit remain unknown.

Disruption as well as point mutations of the rps19 gene in yeast and human cells affect maturation of the pre-ribosomal RNA (pre-rRNA) and block production of the 40S ribosomal subunits. Specifically, mutations in the rps19 gene are associated with the rare congenital disease Diamond-Blackfan anaemia (DBA). S19 forms a five-helix bundle organised around a central amphipathic alpha-helix, which corresponds to the DBA mutation hot spot.

PFAM:PF01090, INTERPRO:IPR001266, INTERPRO:IPR038111,PMID:17726054

GO Diversity

Unique GO annotations
59 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
1769 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 4
Unique GO: 59
Unique Species: 1769