The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 266788: Putative rfx transcription factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P22670 (/IPI) P48378 (/IPI) P48380 (/IPI) P48381 (/IPI) P48382 (/IPI) P48743 (/IPI) Q33E94 (/IPI) Q7TNK1 (/IPI) Q8C7R7 (/IPI) Q8HWS3 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 A0A0B4K621 (/IDA) A0A0B4K653 (/IDA) A0A0B4K6P1 (/IDA) A0A0B4KFL4 (/IDA) A8JQX0 (/IDA) P48381 (/IDA) Q9U1K2 (/IDA) Q9VGZ6 (/IDA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
6 A6QLW9 (/ISS) B1WAV2 (/ISS) P48378 (/ISS) Q4R3Z4 (/ISS) Q5EAP5 (/ISS) Q5RDR2 (/ISS)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
6 A6QLW9 (/ISS) B1WAV2 (/ISS) P48378 (/ISS) Q4R3Z4 (/ISS) Q5EAP5 (/ISS) Q5RDR2 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
6 A0JMF8 (/ISS) D2HNW6 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS) Q5RJA1 (/ISS) Q8C7R7 (/ISS)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
4 B2GV50 (/IDA) P48743 (/IDA) Q32NR3 (/IDA) Q33E94 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 P48378 (/TAS) P48380 (/TAS) P48382 (/TAS) Q14267 (/TAS)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 B2GV50 (/IDA) P48381 (/IDA) Q32NR3 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 P48380 (/NAS) P48382 (/NAS) Q14267 (/NAS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
3 P48380 (/IDA) P48381 (/IDA) Q8HWS3 (/IDA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
2 P48383 (/ISO) Q7TNK1 (/ISO)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 P48379 (/IMP) Q5AMQ6 (/IMP)
Transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705
Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
2 P22670 (/TAS) P48380 (/TAS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P48381 (/ISO) Q8C7R7 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q8HWS3 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 P48379 (/IMP)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q8C7R7 (/ISO)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
1 P48379 (/IMP)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q33E94 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P48383 (/IMP)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q7TNK1 (/ISO)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P48379 (/IC)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q8HWS3 (/IDA)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q8C7R7 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P48377 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q7TNK1 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q5AMQ6 (/IGI)

There are 84 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
8 A6QLW9 (/ISS) B1WAV2 (/ISS) B2GV50 (/ISS) P48378 (/ISS) P48380 (/ISS) Q4R3Z4 (/ISS) Q5EAP5 (/ISS) Q5RDR2 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
7 A0A0B4K621 (/TAS) A0A0B4K653 (/TAS) A0A0B4K6P1 (/TAS) A0A0B4KFL4 (/TAS) A8JQX0 (/TAS) Q9U1K2 (/TAS) Q9VGZ6 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
7 A0A0B4K621 (/IMP) A0A0B4K653 (/IMP) A0A0B4K6P1 (/IMP) A0A0B4KFL4 (/IMP) A8JQX0 (/IMP) Q9U1K2 (/IMP) Q9VGZ6 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
7 A0A0B4K621 (/IMP) A0A0B4K653 (/IMP) A0A0B4K6P1 (/IMP) A0A0B4KFL4 (/IMP) A8JQX0 (/IMP) Q9U1K2 (/IMP) Q9VGZ6 (/IMP)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
7 A0A0B4K621 (/IMP) A0A0B4K653 (/IMP) A0A0B4K6P1 (/IMP) A0A0B4KFL4 (/IMP) A8JQX0 (/IMP) Q9U1K2 (/IMP) Q9VGZ6 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.
7 A0A0B4K621 (/TAS) A0A0B4K653 (/TAS) A0A0B4K6P1 (/TAS) A0A0B4KFL4 (/TAS) A8JQX0 (/TAS) Q9U1K2 (/TAS) Q9VGZ6 (/TAS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 A6QLW9 (/ISS) B1WAV2 (/ISS) P48378 (/ISS) Q4R3Z4 (/ISS) Q5EAP5 (/ISS) Q5RDR2 (/ISS)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
6 A0JMF8 (/ISS) D2HNW6 (/ISS) P48380 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS) Q5RJA1 (/ISS)
Acrosome assembly GO:0001675
The formation of the acrosome from the spermatid Golgi.
5 A6QLW9 (/ISS) B2GV50 (/ISS) P48378 (/ISS) Q4R3Z4 (/ISS) Q5RDR2 (/ISS)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
5 A6QLW9 (/ISS) B2GV50 (/ISS) P48378 (/ISS) Q4R3Z4 (/ISS) Q5RDR2 (/ISS)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
5 A0JMF8 (/ISS) D2HNW6 (/ISS) P48380 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 P48379 (/IMP) P48381 (/IMP) P48743 (/IMP) Q09555 (/IMP) Q8HWS3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
4 A0JMF8 (/ISS) P48380 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 C0P280 (/IMP) G5EBW8 (/IMP) P48379 (/IMP) Q09555 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 D2HNW6 (/ISS) P48380 (/ISS) Q5RJA1 (/ISS) Q8C7R7 (/ISS)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
4 P48379 (/IMP) P48381 (/IMP) Q32NR3 (/IMP) Q7TNK1 (/IMP)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
4 A0JMF8 (/ISS) P48380 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS)
Epithelial cilium movement involved in determination of left/right asymmetry GO:0060287
The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves.
4 A0JMF8 (/ISS) P48380 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P48743 (/IMP) Q5AMQ6 (/IMP) Q9JL61 (/IMP)
Type B pancreatic cell differentiation GO:0003309
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
3 D2HNW6 (/ISS) Q5RJA1 (/ISS) Q8HWS3 (/ISS)
Pancreatic A cell differentiation GO:0003310
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
3 D2HNW6 (/ISS) Q5RJA1 (/ISS) Q8HWS3 (/ISS)
Pancreatic D cell differentiation GO:0003311
The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
3 D2HNW6 (/ISS) Q5RJA1 (/ISS) Q8HWS3 (/ISS)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
3 A0JMF8 (/ISS) Q0V9K5 (/ISS) Q4R3I8 (/ISS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 B2GV50 (/IDA) Q32NR3 (/IDA) Q7TNK1 (/IDA)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
3 P48381 (/IMP) Q5RJA1 (/IMP) Q8HWS3 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
3 D2HNW6 (/ISS) Q5RJA1 (/ISS) Q8C7R7 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 P48380 (/IDA) P48381 (/IDA) Q8HWS3 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 D2HNW6 (/ISS) Q5RJA1 (/ISS) Q8C7R7 (/ISS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 Q33E94 (/IDA) Q7TNK1 (/IDA) Q8HWS3 (/IDA)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
3 P48381 (/IMP) Q8C7R7 (/IMP) Q8HWS3 (/IMP)
Pancreatic epsilon cell differentiation GO:0090104
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin.
3 D2HNW6 (/ISS) Q5RJA1 (/ISS) Q8HWS3 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P48743 (/IGI) Q5AMQ6 (/IGI)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
2 P48381 (/IMP) Q5EAP5 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 Q8C7R7 (/IMP) Q8HWS3 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 D2HNW6 (/ISS) Q5RJA1 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P48381 (/ISO) Q8C7R7 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q7TNK1 (/ISO) Q8C7R7 (/ISO)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P48743 (/IDA)
Acrosome assembly GO:0001675
The formation of the acrosome from the spermatid Golgi.
1 P48379 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 Q32NR3 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 B1WAV2 (/ISS)
Type B pancreatic cell differentiation GO:0003309
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
1 Q8C7R7 (/IMP)
Pancreatic A cell differentiation GO:0003310
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
1 Q8C7R7 (/IMP)
Pancreatic D cell differentiation GO:0003311
The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
1 Q8C7R7 (/IMP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P48381 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P48381 (/IMP)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P22670 (/TAS)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
1 P48379 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q5AMQ6 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010768
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
1 Q5AMQ6 (/IMP)
Dorsal spinal cord development GO:0021516
The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.
1 Q7TNK1 (/IMP)
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
1 Q7TNK1 (/IMP)
Cerebellar cortex morphogenesis GO:0021696
The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
1 Q7TNK1 (/IMP)
Negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning GO:0021914
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.
1 Q7TNK1 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5AMQ6 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q7TNK1 (/IMP)
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
1 Q7TNK1 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 Q8C7R7 (/ISO)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q5AMQ6 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q5AMQ6 (/IMP)
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q5AMQ6 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 Q8HWS3 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 Q8C7R7 (/ISO)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 Q8C7R7 (/ISO)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5AMQ6 (/IMP)
Adhesion of symbiont to host GO:0044406
The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q5AMQ6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P48380 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P48381 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P48381 (/ISS)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
1 P48381 (/IMP)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
1 P48380 (/ISS)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 Q8C7R7 (/ISO)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q32NR3 (/IDA)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 P48381 (/IMP)
Epithelial cilium movement involved in determination of left/right asymmetry GO:0060287
The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves.
1 P48381 (/IMP)
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
1 Q5EAP5 (/IMP)
Regulation of protein processing GO:0070613
Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.
1 Q7TNK1 (/IMP)
Type B pancreatic cell maturation GO:0072560
A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
1 P48381 (/IMP)
Pancreatic epsilon cell differentiation GO:0090104
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin.
1 Q8C7R7 (/IMP)
Negative regulation of filamentous growth of a population of unicellular organisms GO:1900429
Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.
1 Q5AMQ6 (/IMP)
Regulation of non-motile cilium assembly GO:1902855
Any process that modulates the frequency, rate or extent of non-motile cilium assembly.
1 G5EBW8 (/IEP)
Regulation of non-motile cilium assembly GO:1902855
Any process that modulates the frequency, rate or extent of non-motile cilium assembly.
1 G5EBW8 (/IMP)
Positive regulation of type B pancreatic cell development GO:2000078
Any process that activates or increases the frequency, rate or extent of pancreatic B cell development.
1 P48381 (/IMP)
Positive regulation of type B pancreatic cell development GO:2000078
Any process that activates or increases the frequency, rate or extent of pancreatic B cell development.
1 P48380 (/ISS)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 A6QLW9 (/ISS) D2HNW6 (/ISS) P48378 (/ISS) P48379 (/ISS) Q4R3Z4 (/ISS) Q5RDR2 (/ISS) Q5RJA1 (/ISS) Q8HWS3 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 B2GV50 (/IDA) P48383 (/IDA) Q09555 (/IDA) Q7TNK1 (/IDA) Q8C7R7 (/IDA) Q8HWS3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A6QLW9 (/ISS) P48378 (/ISS) P48379 (/ISS) Q4R3Z4 (/ISS) Q5RDR2 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
3 P48380 (/IDA) P48381 (/IDA) P48383 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P48383 (/ISO) Q8C7R7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P48380 (/TAS) P48382 (/TAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
2 P48380 (/IC) P48381 (/IC)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P48381 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P48380 (/IC)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P22670 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P48377 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8HWS3 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8C7R7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 B2GV50 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P48383 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P22670 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P48377 (/ISO)