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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 266227: GntR family transcriptional regulator

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aspartate transaminase. [EC: 2.6.1.1]
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
  • Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.
  • This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
 304 A0A023YXA2 A0A023YXA2 A0A023Z752 A0A023Z752 A0A024KLU5 A0A024KLU5 A0A024L7C8 A0A024L7C8 A0A025C6E0 A0A025C6E0
(294 more...)
2-aminoadipate transaminase. [EC: 2.6.1.39]
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
    		 90 A0A024L3R4 A0A024L3R4 A0A029KWZ1 A0A029KWZ1 A0A070UY25 A0A070UY25 A0A0A0FBZ7 A0A0A0FBZ7 A0A0E1LX26 A0A0E1LX26
    (80 more...)
    Aromatic-amino-acid transaminase. [EC: 2.6.1.57]
    An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
    • L-methionine can also act as donor, more slowly.
    • Oxaloacetate can act as acceptor.
    • Controlled proteolysis converts the enzyme to EC 2.6.1.1.
    		 34 A0A031G5C6 A0A031G5C6 A0A059L6X7 A0A059L6X7 A0A0C2RM82 A0A0C2RM82 A0A0F4T156 A0A0F4T156 A0A0Q6Q4Y2 A0A0Q6Q4Y2
    (24 more...)
    Tyrosine transaminase. [EC: 2.6.1.5]
    L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
    • L-phenylalanine can act instead of L-tyrosine.
    • The mitochondrial enzyme may be identical with EC 2.6.1.1.
    • The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33.
    • The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.
    		 2 A8AWU4 A8AWU4
    Glycine hydroxymethyltransferase. [EC: 2.1.2.1]
    5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
    • Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.
    		 2 A0A073CBQ0 A0A073CBQ0
    Histidinol-phosphate transaminase. [EC: 2.6.1.9]
    L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
      		 2 A0A085U887 A0A085U887