The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 266193: ArsR family transcriptional regulator

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Arsenate-mycothiol transferase. [EC: 2.8.4.2]
Arsenate + mycothiol = arseno-mycothiol + H(2)O.
  • Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate.
  • The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide.
  • Finally, a second mycothiol recycles mycoredoxin and forms mycothione.
5 A0A0F0KQU4 A0A0F0KSA7 A0A0F0L573 A0A150H8N2 A0A161HR04
Arsenate reductase (glutaredoxin). [EC: 1.20.4.1]
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
  • The enzyme is part of a system for detoxifying arsenate.
  • Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4).
  • Formerly EC 1.97.1.5.
5 A0A0W8FA01 A0A137SIS4 D0I9T5 R9PRW9 U4TE44
Protein-tyrosine-phosphatase. [EC: 3.1.3.48]
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
  • Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
4 A0A061CZA3 A0A087D1E7 A0A1C7BWU4 W6R4K3