The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 265372: Vacuolar membrane-associated protein IML1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 P47170 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 P47170 (/IMP)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 O74788 (/ISO)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P47170 (/IMP)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
1 P47170 (/IGI)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
1 P47170 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 P47170 (/IDA)
Negative regulation of small GTPase mediated signal transduction GO:0051058
Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
1 P47170 (/IGI)
Regulation of autophagosome assembly GO:2000785
Any process that modulates the frequency, rate or extent of autophagosome assembly.
1 P47170 (/IMP)
Regulation of autophagosome assembly GO:2000785
Any process that modulates the frequency, rate or extent of autophagosome assembly.
1 O74788 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Seh1-associated complex GO:0035859
A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.
1 P47170 (/IDA)
Seh1-associated complex GO:0035859
A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.
1 O74788 (/ISO)
Extrinsic component of fungal-type vacuolar membrane GO:0097042
The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 P47170 (/IDA)
GATOR1 complex GO:1990130
A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
1 P47170 (/IDA)
GATOR1 complex GO:1990130
A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
1 O74788 (/ISO)